APOA2

APOA2
بنى متوفرة
بنك بيانات البروتين	Ortholog search: PDBe RCSB
قائمة رموز معرفات بنك بيانات البروتين
	1L6L, 2OU1
معرفات
أسماء بديلة	APOA2, Apo-AII, ApoA-II, apoAII, Apolipoprotein A2
معرفات خارجية	الوراثة المندلية البشرية عبر الإنترنت 107670 MGI: MGI:88050 HomoloGene: 1242 GeneCards: 336
علم الوجود الجيني
وظائف جزيئية	• lipase inhibitor activity; • protein homodimerization activity; • phosphatidylcholine binding; • lipid transporter activity; • apolipoprotein receptor binding; • high-density lipoprotein particle receptor binding; • cholesterol binding; • GO:0001948، GO:0016582 ربط بروتيني; • protein heterodimerization activity; • phosphatidylcholine-sterol O-acyltransferase activator activity; • phospholipid binding; • GO:0017127 cholesterol transfer activity; • lipid binding; • high-density lipoprotein particle binding; • heat shock protein binding; • signaling receptor binding;
مكونات خلوية	• عصارة خلوية; • blood microparticle; • endoplasmic reticulum lumen; • كيلومكرون; • very-low-density lipoprotein particle; • spherical high-density lipoprotein particle; • الفراغ خارج الخلية; • early endosome; • high-density lipoprotein particle; • حويصلة خارج خلوية; • خارج خلوي;
عمليات حيوية	• negative regulation of cholesterol import; • negative regulation of very-low-density lipoprotein particle remodeling; • diacylglycerol catabolic process; • lipid transport; • regulation of protein stability; • positive regulation of cholesterol esterification; • phospholipid efflux; • cholesterol transport; • positive regulation of lipid catabolic process; • response to glucocorticoid; • GO:0002719 negative regulation of cytokine production involved in immune response; • response to glucose; • high-density lipoprotein particle assembly; • retinoid metabolic process; • response to estrogen; • high-density lipoprotein particle remodeling; • negative regulation of lipase activity; • regulation of intestinal cholesterol absorption; • low-density lipoprotein particle remodeling; • acute inflammatory response; • animal organ regeneration; • phospholipid catabolic process; • peptidyl-methionine modification; • cholesterol efflux; • negative regulation of cholesterol transport; • cholesterol homeostasis; • phosphatidylcholine biosynthetic process; • negative regulation of cholesterol transporter activity; • GO:0022415 viral process; • negative regulation of lipid catabolic process; • triglyceride-rich lipoprotein particle remodeling; • triglyceride metabolic process; • reverse cholesterol transport; • high-density lipoprotein particle clearance; • GO:0048554 positive regulation of catalytic activity; • cholesterol metabolic process; • regulation of lipid metabolic process; • chylomicron remodeling; • chylomicron assembly; • lipoprotein metabolic process; • تعديل ما بعد الترجمة; • GO:0015915 نقل; • positive regulation of phagocytosis; • protein stabilization;
	المصادر:Amigo / QuickGO
نمط التعبير عن الحمض النووي الريبوزي
	; ;
	المزيد من بيانات التعبير المرجعية
تماثلات متسلسلة
	P02652
	P09813
	NM_001643
	NM_001305549، NM_001305550، NM_001305585، NR_131173 NM_013474، NM_001305549، NM_001305550، NM_001305585، NR_131173
	NP_001634
	NP_001292479، NP_001292514، NP_038502 NP_001292478، NP_001292479، NP_001292514، NP_038502
	ويكي بيانات
اعرض/عدّل إنسان	اعرض/عدّل فأر

APOA2‏ (Apolipoprotein A2) هوَ بروتين يُشَفر بواسطة جين APOA2 في الإنسان.^[1]

الوظيفة

الأهمية السريرية

المراجع

^ Tsao YK، Wei CF، Robberson DL، Gotto AM، Chan L (ديسمبر 1985). "Isolation and characterization of the human apolipoprotein A-II gene. Electron microscopic analysis of RNA:DNA hybrids, nucleotide sequence, identification of a polymorphic MspI site, and general structural organization of apolipoprotein genes". The Journal of Biological Chemistry. ج. 260 ع. 28: 15222–31. PMID:2415515.

قراءة متعمقة

Blanco-Vaca F، Escolà-Gil JC، Martín-Campos JM، Julve J (نوفمبر 2001). "Role of apoA-II in lipid metabolism and atherosclerosis: advances in the study of an enigmatic protein". Journal of Lipid Research. ج. 42 ع. 11: 1727–39. PMID:11714842.
Kalopissis AD، Pastier D، Chambaz J (أبريل 2003). "Apolipoprotein A-II: beyond genetic associations with lipid disorders and insulin resistance". Current Opinion in Lipidology. ج. 14 ع. 2: 165–72. DOI:10.1097/00041433-200304000-00008. PMID:12642785.
Vollmer E، Brust J، Roessner A، Bosse A، Burwikel F، Kaesberg B، Harrach B، Robenek H، Böcker W (1991). "Distribution patterns of apolipoproteins A1, A2, and B in the wall of atherosclerotic vessels". Virchows Archiv A. ج. 419 ع. 2: 79–88. DOI:10.1007/BF01600220. PMID:1908160.
Deeb SS، Takata K، Peng RL، Kajiyama G، Albers JJ (أبريل 1990). "A splice-junction mutation responsible for familial apolipoprotein A-II deficiency". American Journal of Human Genetics. ج. 46 ع. 4: 822–7. PMC:1683675. PMID:2107739.
Gordon JI، Sims HF، Edelstein C، Scanu AM، Strauss AW (نوفمبر 1985). "Extracellular processing of proapolipoprotein A-II in Hep G2 cell cultures is mediated by a 54-kDa protease immunologically related to cathepsin B". The Journal of Biological Chemistry. ج. 260 ع. 27: 14824–31. PMID:2414299.
Lackner KJ، Law SW، Brewer HB (يونيو 1985). "The human apolipoprotein A-II gene: complete nucleic acid sequence and genomic organization". Nucleic Acids Research. ج. 13 ع. 12: 4597–608. DOI:10.1093/nar/13.12.4597. PMC:321808. PMID:2989800.
Knott TJ، Wallis SC، Robertson ME، Priestley LM، Urdea M، Rall LB، Scott J (سبتمبر 1985). "The human apolipoprotein AII gene: structural organization and sites of expression". Nucleic Acids Research. ج. 13 ع. 17: 6387–98. DOI:10.1093/nar/13.17.6387. PMC:321960. PMID:2995928.
Chan L، Moore MN، Tsao YK (1986). "Molecular cloning and sequence analysis of human apolipoprotein A-II cDNA". Methods in Enzymology. ج. 128: 745–52. DOI:10.1016/0076-6879(86)28103-3. ISBN:978-0-12-182028-2. PMID:3088392. مؤرشف من الأصل في 2019-12-07.
Middleton-Price HR، van den Berghe JA، Scott J، Knott TJ، Malcolm S (يوليو 1988). "Regional chromosomal localisation of APOA2 to 1q21-1q23". Human Genetics. ج. 79 ع. 3: 283–5. DOI:10.1007/BF00366253. PMID:3136074.
Shelley CS، Sharpe CR، Baralle FE، Shoulders CC (نوفمبر 1985). "Comparison of the human apolipoprotein genes. Apo AII presents a unique functional intron-exon junction". Journal of Molecular Biology. ج. 186 ع. 1: 43–51. DOI:10.1016/0022-2836(85)90255-4. PMID:3935800.
Brewer HB، Lux SE، Ronan R، John KM (مايو 1972). "Amino acid sequence of human apoLp-Gln-II (apoA-II), an apolipoprotein isolated from the high-density lipoprotein complex". Proceedings of the National Academy of Sciences of the United States of America. ج. 69 ع. 5: 1304–8. DOI:10.1073/pnas.69.5.1304. PMC:426687. PMID:4338591.
Lux SE، John KM، Ronan R، Brewer HB (ديسمبر 1972). "Isolation and characterization of the tryptic and cyanogen bromide peptides of apoLp-Gln-II (apoA-II), plasma high density apolipoprotein". The Journal of Biological Chemistry. ج. 247 ع. 23: 7519–27. PMID:4344225.
Moore MN، Kao FT، Tsao YK، Chan L (أغسطس 1984). "Human apolipoprotein A-II: nucleotide sequence of a cloned cDNA, and localization of its structural gene on human chromosome 1". Biochemical and Biophysical Research Communications. ج. 123 ع. 1: 1–7. DOI:10.1016/0006-291X(84)90371-1. PMID:6089788.
Lackner KJ، Law SW، Brewer HB (سبتمبر 1984). "Human apolipoprotein A-II: complete nucleic acid sequence of preproapo A-II". FEBS Letters. ج. 175 ع. 1: 159–64. DOI:10.1016/0014-5793(84)80590-6. PMID:6090207.
Gordon JI، Budelier KA، Sims HF، Edelstein C، Scanu AM، Strauss AW (نوفمبر 1983). "Biosynthesis of human preproapolipoprotein A-II". The Journal of Biological Chemistry. ج. 258 ع. 22: 14054–9. PMID:6315718.
Sharpe CR، Sidoli A، Shelley CS، Lucero MA، Shoulders CC، Baralle FE (مايو 1984). "Human apolipoproteins AI, AII, CII and CIII. cDNA sequences and mRNA abundance". Nucleic Acids Research. ج. 12 ع. 9: 3917–32. DOI:10.1093/nar/12.9.3917. PMC:318799. PMID:6328445.
Stoffel W، Krüger E، Deutzmann R (مارس 1983). "Cell-free translation of human liver apolipoprotein AI and AII mRNA. Processing of primary translation products". Hoppe-Seyler's Zeitschrift für Physiologische Chemie. ج. 364 ع. 3: 227–37. DOI:10.1515/bchm2.1983.364.1.227. PMID:6407957.
Knott TJ، Priestley LM، Urdea M، Scott J (مايو 1984). "Isolation and characterisation of a cDNA encoding the precursor for human apolipoprotein AII". Biochemical and Biophysical Research Communications. ج. 120 ع. 3: 734–40. DOI:10.1016/S0006-291X(84)80168-0. PMID:6428397.
Lackner KJ، Law SW، Brewer HB، Sakaguchi AY، Naylor SL (أغسطس 1984). "The human apolipoprotein A-II gene is located on chromosome 1". Biochemical and Biophysical Research Communications. ج. 122 ع. 3: 877–83. DOI:10.1016/0006-291X(84)91172-0. PMID:6433912.

[pmid2415515-1] Tsao YK، Wei CF، Robberson DL، Gotto AM، Chan L (ديسمبر 1985). "Isolation and characterization of the human apolipoprotein A-II gene. Electron microscopic analysis of RNA:DNA hybrids, nucleotide sequence, identification of a polymorphic MspI site, and general structural organization of apolipoprotein genes". The Journal of Biological Chemistry. ج. 260 ع. 28: 15222–31. PMID:2415515.

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