CST4

CST4
معرفات
أسماء بديلة	CST4, cystatin S
معرفات خارجية	الوراثة المندلية البشرية عبر الإنترنت 123857 GeneCards: 1472
علم الوجود الجيني
وظائف جزيئية	• peptidase inhibitor activity; • cysteine-type endopeptidase inhibitor activity; • protease binding;
مكونات خلوية	• الفراغ خارج الخلية; • حويصلة خارج خلوية; • خارج خلوي;
عمليات حيوية	• negative regulation of proteolysis; • retina homeostasis; • negative regulation of peptidase activity; • detection of chemical stimulus involved in sensory perception of bitter taste; • negative regulation of cysteine-type endopeptidase activity; • negative regulation of endopeptidase activity;
	المصادر:Amigo / QuickGO
تماثلات متسلسلة
	P01036
	n/a
	NM_001899
	n/a
	NP_001890
	n/a
	ويكي بيانات
اعرض/عدّل إنسان

CST4‏ (Cystatin S) هوَ بروتين يُشَفر بواسطة جين CST4 في الإنسان.^[1]^[2]

الوظيفة

الأهمية السريرية

المراجع

^ "Entrez Gene: CST4 cystatin S". مؤرشف من الأصل في 2010-12-05.
^ Saitoh E، Isemura S، Sanada K، Ohnishi K (أبريل 1992). "The human cystatin gene family: cloning of three members and evolutionary relationship between cystatins and Bowman-Birk type proteinase inhibitors". Biomed Biochim Acta. ج. 50 ع. 4–6: 599–605. PMID:1801729.

قراءة متعمقة

Brown WM، Dziegielewska KM (1997). "Friends and relations of the cystatin superfamily--new members and their evolution". Protein Sci. ج. 6 ع. 1: 5–12. DOI:10.1002/pro.5560060102. PMC:2143511. PMID:9007972.
Saitoh E، Isemura S، Sanada K، Ohnishi K (1993). "Characterization of two members (CST4 and CST5) of the cystatin gene family and molecular evolution of cystatin genes". Agents Actions Suppl. ج. 38 ع. 1: 340–8. DOI:10.1007/978-3-0348-7321-5_43. PMID:1334620.
Takahashi M، Honda Y، Ogawa K، Barka T (1993). "Immunofluorescence localization of cystatins in human lacrimal gland and in the exorbital lacrimal gland of the rat". Acta Ophthalmologica. ج. 70 ع. 5: 625–31. DOI:10.1111/j.1755-3768.1992.tb02143.x. PMID:1471486.
Johnsson M، Richardson CF، Bergey EJ، وآخرون (1992). "The effects of human salivary cystatins and statherin on hydroxyapatite crystallization". Arch. Oral Biol. ج. 36 ع. 9: 631–6. DOI:10.1016/0003-9969(91)90014-L. PMID:1741693.
Ramasubbu N، Reddy MS، Bergey EJ، وآخرون (1992). "Large-scale purification and characterization of the major phosphoproteins and mucins of human submandibular-sublingual saliva". Biochem. J. ج. 280 ع. 2: 341–52. PMC:1130552. PMID:1747107.
Isemura S، Saitoh E، Sanada K، Minakata K (1992). "Identification of full-sized forms of salivary (S-type) cystatins (cystatin SN, cystatin SA, cystatin S, and two phosphorylated forms of cystatin S) in human whole saliva and determination of phosphorylation sites of cystatin S". J. Biochem. ج. 110 ع. 4: 648–54. PMID:1778989.
Lamkin MS، Jensen JL، Setayesh MR، وآخرون (1991). "Salivary cystatin SA-III, a potential precursor of the acquired enamel pellicle, is phosphorylated at both its amino- and carboxyl-terminal regions". Arch. Biochem. Biophys. ج. 288 ع. 2: 664–70. DOI:10.1016/0003-9861(91)90249-I. PMID:1898055.
Bobek LA، Aguirre A، Levine MJ (1991). "Human salivary cystatin S. Cloning, sequence analysis, hybridization in situ and immunocytochemistry". Biochem. J. ج. 278 ع. 3: 627–35. PMC:1151393. PMID:1898352.
Freije JP، Abrahamson M، Olafsson I، وآخرون (1991). "Structure and expression of the gene encoding cystatin D, a novel human cysteine proteinase inhibitor". J. Biol. Chem. ج. 266 ع. 30: 20538–43. PMID:1939105.
Saitoh E، Isemura S، Sanada K، وآخرون (1989). "Cystatin superfamily. Evidence that family II cystatin genes are evolutionarily related to family III cystatin genes". Biol. Chem. Hoppe-Seyler. 369 Suppl: 191–7. PMID:3202964.
Hawke DH، Yuan PM، Wilson KJ، Hunkapiller MW (1987). "Identification of a long form of cystatin from human saliva by rapid microbore HPLC mapping". Biochem. Biophys. Res. Commun. ج. 145 ع. 3: 1248–53. DOI:10.1016/0006-291X(87)91571-3. PMID:3496880.
Isemura S، Saitoh E، Ito S، وآخرون (1985). "Cystatin S: a cysteine proteinase inhibitor of human saliva". J. Biochem. ج. 96 ع. 4: 1311–4. PMID:6394600.
Isemura S، Saitoh E، Sanada K (1985). "Isolation and amino acid sequence of SAP-1, an acidic protein of human whole saliva, and sequence homology with human gamma-trace". J. Biochem. ج. 96 ع. 2: 489–98. PMID:6501254.
Dickinson DP، Thiesse M، Dempsey LD، Millar SJ (1993). "Genomic cloning, physical mapping, and expression of human type 2 cystatin genes". Crit. Rev. Oral Biol. Med. ج. 4 ع. 3–4: 573–80. PMID:7690606.
Dickinson DP، Zhao Y، Thiesse M، Siciliano MJ (1995). "Direct mapping of seven genes encoding human type 2 cystatins to a single site located at 20p11.2". Genomics. ج. 24 ع. 1: 172–5. DOI:10.1006/geno.1994.1595. PMID:7896273.
Thiesse M، Millar SJ، Dickinson DP (1994). "The human type 2 cystatin gene family consists of eight to nine members, with at least seven genes clustered at a single locus on human chromosome 20". DNA Cell Biol. ج. 13 ع. 2: 97–116. DOI:10.1089/dna.1994.13.97. PMID:8179826.
Henskens YM، van den Keijbus PA، Veerman EC، وآخرون (1996). "Protein composition of whole and parotid saliva in healthy and periodontitis subjects. Determination of cystatins, albumin, amylase and IgA". J. Periodont. Res. ج. 31 ع. 1: 57–65. DOI:10.1111/j.1600-0765.1996.tb00464.x. PMID:8636877.
Baron A، DeCarlo A، Featherstone J (2000). "Functional aspects of the human salivary cystatins in the oral environment". Oral diseases. ج. 5 ع. 3: 234–40. DOI:10.1111/j.1601-0825.1999.tb00307.x. PMID:10483070.

[entrez-1] "Entrez Gene: CST4 cystatin S". مؤرشف من الأصل في 2010-12-05.

[pmid1801729-2] Saitoh E، Isemura S، Sanada K، Ohnishi K (أبريل 1992). "The human cystatin gene family: cloning of three members and evolutionary relationship between cystatins and Bowman-Birk type proteinase inhibitors". Biomed Biochim Acta. ج. 50 ع. 4–6: 599–605. PMID:1801729.

[1]

[2]

التصنيفات الطبية	دليل الوراثة المندلية عند البشر (OMIM): 123857
المعرفات الخارجية	Ensembl Transcript ID: ENST00000217423 نظام اللغة الطبية الموحدة (UMLS CUI): C1413773