Integrin alpha 2b

ITGA2B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1DPK, 1DPQ, 1KUP, 1KUZ, 1M8O, 1S4W, 1TYE, 2K1A, 2K9J, 2KNC, 2MTP, 2VC2, 2VDK, 2VDL, 2VDM, 2VDN, 2VDO, 2VDP, 2VDQ, 2VDR, 3FCS, 3FCU, 3NID, 3NIF, 3NIG, 3T3M, 3T3P, 3ZDX, 3ZDY, 3ZDZ, 3ZE0, 3ZE1, 3ZE2, 4CAK, 4Z7O, 4Z7Q, 5HDB, 4Z7N
Identifiers
Aliases	ITGA2B, BDPLT16, BDPLT2, CD41, CD41B, GP2B, GPIIb, GT, GTA, HPA3, PPP1R93, integrin subunit alpha 2b, GT1
External IDs	OMIM: 607759; MGI: 96601; HomoloGene: 37304; GeneCards: ITGA2B; OMA:ITGA2B - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	44,389,649 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	102,360,948 bp
RNA expression pattern
	Top expressed in
	monocyte; ; blood; ; trabecular bone; ; granulocyte; ; pancreatic ductal cell; ; gonad; ; testicle; ; right hemisphere of cerebellum; ; bone marrow cell; ; sperm;
	Top expressed in
	blood; ; tibiofemoral joint; ; embryo; ; yolk sac; ; spleen; ; lip; ; body of femur; ; right kidney; ; gastrula; ; granulocyte;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; fibrinogen binding; extracellular matrix binding; identical protein binding; metal ion binding;
Cellular component	focal adhesion; integrin complex; integral component of plasma membrane; platelet alpha granule membrane; integral component of membrane; membrane; external side of plasma membrane; extracellular exosome; plasma membrane; blood microparticle; cell surface;
Biological process	extracellular matrix organization; cell-matrix adhesion; positive regulation of leukocyte migration; platelet aggregation; platelet degranulation; cell adhesion; integrin-mediated signaling pathway; regulation of megakaryocyte differentiation;
	Sources:Amigo / QuickGO
Orthologs
	3674
	16399
	ENSG00000005961
	ENSMUSG00000034664
	P08514
	Q9QUM0
	NM_000419
	NM_010575
	NP_000410
	NP_034705
	Wikidata
View/Edit Human	View/Edit Mouse

Integrin alpha-IIb is a protein that in humans is encoded by the ITGA2B gene. ITGA2B, also known as CD41, encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibrinogen receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. At least 38 disease-causing mutations in this gene have been discovered.^[5] In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.^[6]

Interactions

ITGA2B has been shown to interact with AUP1^[7] and CLNS1A.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000005961 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000034664 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Šimčíková D, Heneberg P (December 2019). "Refinement of evolutionary medicine predictions based on clinical evidence for the manifestations of Mendelian diseases". Scientific Reports. 9 (1) 18577. Bibcode:2019NatSR...918577S. doi:10.1038/s41598-019-54976-4. PMC 6901466. PMID 31819097.
^ "Entrez Gene: ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)".
^ Kato A, Kawamata Norihiko, Tamayose Kenji, Egashira Motoki, Miura Rika, Fujimura Tsutomu, Murayama Kimie, Oshimi Kazuo (Aug 2002). "Ancient ubiquitous protein 1 binds to the conserved membrane-proximal sequence of the cytoplasmic tail of the integrin alpha subunits that plays a crucial role in the inside-out signaling of alpha IIbbeta 3". J. Biol. Chem. 277 (32). United States: 28934–41. doi:10.1074/jbc.M204340200. ISSN 0021-9258. PMID 12042322.
^ Larkin D, Murphy Derek, Reilly Dermot F, Cahill Martha, Sattler Ellen, Harriott Pat, Cahill Dolores J, Moran Niamh (Jun 2004). "ICln, a novel integrin alphaIIbbeta3-associated protein, functionally regulates platelet activation". J. Biol. Chem. 279 (26). United States: 27286–93. doi:10.1074/jbc.M402159200. ISSN 0021-9258. PMID 15075326.

External links

CD41+Antigen at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Overview of all the structural information available in the PDB for UniProt: P08514 (Human Integrin alpha-IIb) at the PDBe-KB.

This membrane protein–related article is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000005961 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000034664 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Šimčíková_2019_-_supplementary_table_S7-5] Šimčíková D, Heneberg P (December 2019). "Refinement of evolutionary medicine predictions based on clinical evidence for the manifestations of Mendelian diseases". Scientific Reports. 9 (1) 18577. Bibcode:2019NatSR...918577S. doi:10.1038/s41598-019-54976-4. PMC 6901466. PMID 31819097.

[6] "Entrez Gene: ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)".

[pmid12042322-7] Kato A, Kawamata Norihiko, Tamayose Kenji, Egashira Motoki, Miura Rika, Fujimura Tsutomu, Murayama Kimie, Oshimi Kazuo (Aug 2002). "Ancient ubiquitous protein 1 binds to the conserved membrane-proximal sequence of the cytoplasmic tail of the integrin alpha subunits that plays a crucial role in the inside-out signaling of alpha IIbbeta 3". J. Biol. Chem. 277 (32). United States: 28934–41. doi:10.1074/jbc.M204340200. ISSN 0021-9258. PMID 12042322.

[pmid15075326-8] Larkin D, Murphy Derek, Reilly Dermot F, Cahill Martha, Sattler Ellen, Harriott Pat, Cahill Dolores J, Moran Niamh (Jun 2004). "ICln, a novel integrin alphaIIbbeta3-associated protein, functionally regulates platelet activation". J. Biol. Chem. 279 (26). United States: 27286–93. doi:10.1074/jbc.M402159200. ISSN 0021-9258. PMID 15075326.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

v t e Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1–50	CD1 a-c 1A 1B 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51–100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101–150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151–200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201–250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249
251–300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301–350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD327 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350
Category Commons

Integrin alpha 2b

Interactions

See also

References

Further reading

External links