CEACAM5

CEACAM5
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	1E07, 2QSQ, 2QST, 2VER
Identifiers
Aliases	CEACAM5, CD66e, CEA, carcinoembryonic antigen related cell adhesion molecule 5, CEA cell adhesion molecule 5
External IDs	OMIM: 114890; HomoloGene: 128801; GeneCards: CEACAM5; OMA:CEACAM5 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	41,730,433 bp
RNA expression pattern
	Top expressed in
	mucosa of ileum; ; mucosa of sigmoid colon; ; nasal epithelium; ; rectum; ; mucosa of transverse colon; ; mucosa of pharynx; ; appendix; ; oral cavity; ; palpebral conjunctiva; ; trachea;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	GPI anchor binding; protein homodimerization activity; identical protein binding;
Cellular component	anchored component of membrane; basolateral plasma membrane; integral component of plasma membrane; extracellular exosome; membrane; integral component of external side of plasma membrane; extracellular region; plasma membrane; cell surface; apical plasma membrane;
Biological process	homotypic cell-cell adhesion; negative regulation of apoptotic process; negative regulation of anoikis; negative regulation of myotube differentiation; C-terminal protein lipidation; leukocyte migration; apoptotic process; cell adhesion; homophilic cell adhesion via plasma membrane adhesion molecules; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;
	Sources:Amigo / QuickGO
Orthologs
	1048
	n/a
	ENSG00000105388
	n/a
	P06731
	n/a
	NM_001291484; NM_001308398; NM_004363
	n/a
	NP_001278413; NP_001295327; NP_004354
	n/a
	Wikidata
View/Edit Human

Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) also known as CD66e (Cluster of Differentiation 66e), is a member of the carcinoembryonic antigen (CEA) gene family.^[3]

Functions

In the literature, CEACAM5 is often used as a synonym for cancer embryonic antigen (CEA), a well-known biomarker of many types of malignancies, such as colorectal cancer and non-small-cell lung cancer.^[4]^[5] Its primary function in the embryonic intestine and colon tumors is adhesion between epithelial cells.^[6] Also, it plays a significant role in the inhibition of differentiation ^[7] and apoptosis ^[8] in colon cells. There are evidences that high CEACAM5 expression is firmly associated with the CD133-positive colorectal cancer stem cells.^[9] High CEACAM5 expression has also been identified in ~25% of patients with advanced non-squamous (NSq) non-small cell lung cancer (NSCLC) detectable via IHC (immunohistochemistry).^[10]^[11]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000105388 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5".
^ Beauchemin N, Arabzadeh A (December 2013). "Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) in cancer progression and metastasis". Cancer and Metastasis Reviews. 32 (3–4): 643–671. doi:10.1007/s10555-013-9444-6. PMID 23903773. S2CID 10344352.
^ Zhang X, Han X, Zuo P, Zhang X, Xu H (September 2020). "CEACAM5 stimulates the progression of non-small-cell lung cancer by promoting cell proliferation and migration". The Journal of International Medical Research. 48 (9) 300060520959478. doi:10.1177/0300060520959478. PMC 7536504. PMID 32993395.
^ Benchimol S, Fuks A, Jothy S, Beauchemin N, Shirota K, Stanners CP (April 1989). "Carcinoembryonic antigen, a human tumor marker, functions as an intercellular adhesion molecule". Cell. 57 (2): 327–334. doi:10.1016/0092-8674(89)90970-7. PMID 2702691. S2CID 30740594.
^ Ilantzis C, DeMarte L, Screaton RA, Stanners CP (2002). "Deregulated expression of the human tumor marker CEA and CEA family member CEACAM6 disrupts tissue architecture and blocks colonocyte differentiation". Neoplasia. 4 (2): 151–163. doi:10.1038/sj.neo.7900201. PMC 1550325. PMID 11896570.
^ Ordoñez C, Screaton RA, Ilantzis C, Stanners CP (July 2000). "Human carcinoembryonic antigen functions as a general inhibitor of anoikis". Cancer Research. 60 (13): 3419–3424. PMID 10910050.
^ Gisina A, Novikova S, Kim Y, Sidorov D, Bykasov S, Volchenko N, et al. (2021-01-01). "CEACAM5 overexpression is a reliable characteristic of CD133-positive colorectal cancer stem cells". Cancer Biomarkers. 32 (1): 85–98. doi:10.3233/CBM-203187. PMID 34092615. S2CID 235359543.
^ LaPointe N, Hertle N, Hsu SC, Kellis J, King N, Littrell J, et al. (2021-05-20). "Validation of an immunohistochemical assay, CEACAM5 IHC 769, under development for use with the antibody-drug conjugate tusamitamab ravtansine (SAR408701)". Journal of Clinical Oncology. 39 (15_suppl) e21030. doi:10.1200/JCO.2021.39.15_suppl.e21030. ISSN 0732-183X. S2CID 236398737.
^ Kim YJ, Li W, Zhelev DV, Mellors JW, Dimitrov DS, Baek DS (2023-02-27). "Chimeric antigen receptor-T cells are effective against CEACAM5 expressing non-small cell lung cancer cells resistant to antibody-drug conjugates". Frontiers in Oncology. 13 1124039. doi:10.3389/fonc.2023.1124039. PMC 10010383. PMID 36923424.

Willcocks TC, Craig IW (November 1990). "Characterization of the genomic organization of human carcinoembryonic antigen (CEA): comparison with other family members and sequence analysis of 5' controlling region". Genomics. 8 (3): 492–500. doi:10.1016/0888-7543(90)90036-T. PMID 2286372.
Barnett T, Zimmermann W (1990). "Workshop report: proposed nomenclature for the carcinoembryonic antigen (CEA) gene family". Tumour Biology. 11 (1–2): 59–63. doi:10.1159/000217643. PMID 2309067.
Schrewe H, Thompson J, Bona M, Hefta LJ, Maruya A, Hassauer M, et al. (June 1990). "Cloning of the complete gene for carcinoembryonic antigen: analysis of its promoter indicates a region conveying cell type-specific expression". Molecular and Cellular Biology. 10 (6): 2738–2748. doi:10.1128/MCB.10.6.2738. PMC 360634. PMID 2342461.
Kamarck ME, Elting JJ, Hart JT, Goebel SJ, Rae PM, Nothdurft MA, et al. (August 1987). "Carcinoembryonic antigen family: expression in a mouse L-cell transfectant and characterization of a partial cDNA in bacteriophage lambda gt11". Proceedings of the National Academy of Sciences of the United States of America. 84 (15): 5350–5354. Bibcode:1987PNAS...84.5350K. doi:10.1073/pnas.84.15.5350. PMC 298853. PMID 2955415.
Zimmermann W, Ortlieb B, Friedrich R, von Kleist S (May 1987). "Isolation and characterization of cDNA clones encoding the human carcinoembryonic antigen reveal a highly conserved repeating structure". Proceedings of the National Academy of Sciences of the United States of America. 84 (9): 2960–2964. Bibcode:1987PNAS...84.2960Z. doi:10.1073/pnas.84.9.2960. PMC 304780. PMID 3033671.
Barnett T, Goebel SJ, Nothdurft MA, Elting JJ (July 1988). "Carcinoembryonic antigen family: characterization of cDNAs coding for NCA and CEA and suggestion of nonrandom sequence variation in their conserved loop-domains". Genomics. 3 (1): 59–66. doi:10.1016/0888-7543(88)90160-7. PMID 3220478.
Zimmermann W, Weber B, Ortlieb B, Rudert F, Schempp W, Fiebig HH, et al. (May 1988). "Chromosomal localization of the carcinoembryonic antigen gene family and differential expression in various tumors". Cancer Research. 48 (9): 2550–2554. PMID 3356015.
Beauchemin N, Benchimol S, Cournoyer D, Fuks A, Stanners CP (September 1987). "Isolation and characterization of full-length functional cDNA clones for human carcinoembryonic antigen". Molecular and Cellular Biology. 7 (9): 3221–3230. doi:10.1128/MCB.7.9.3221. PMC 367958. PMID 3670312.
Oikawa S, Nakazato H, Kosaki G (January 1987). "Primary structure of human carcinoembryonic antigen (CEA) deduced from cDNA sequence". Biochemical and Biophysical Research Communications. 142 (2): 511–518. Bibcode:1987BBRC..142..511O. doi:10.1016/0006-291X(87)90304-4. PMID 3814146.
Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Hart SP, Ross JA, Ross K, Haslett C, Dransfield I (May 2000). "Molecular characterization of the surface of apoptotic neutrophils: implications for functional downregulation and recognition by phagocytes". Cell Death and Differentiation. 7 (5): 493–503. doi:10.1038/sj.cdd.4400680. PMID 10800083.
Guignot J, Peiffer I, Bernet-Camard MF, Lublin DM, Carnoy C, Moseley SL, Servin AL (June 2000). "Recruitment of CD55 and CD66e brush border-associated glycosylphosphatidylinositol-anchored proteins by members of the Afa/Dr diffusely adhering family of Escherichia coli that infect the human polarized intestinal Caco-2/TC7 cells". Infection and Immunity. 68 (6): 3554–3563. doi:10.1128/IAI.68.6.3554-3563.2000. PMC 97642. PMID 10816511.
Boehm MK, Perkins SJ (June 2000). "Structural models for carcinoembryonic antigen and its complex with the single-chain Fv antibody molecule MFE23". FEBS Letters. 475 (1): 11–16. Bibcode:2000FEBSL.475...11B. doi:10.1016/S0014-5793(00)01612-4. PMID 10854848. S2CID 5765612.
Screaton RA, DeMarte L, Dráber P, Stanners CP (August 2000). "The specificity for the differentiation blocking activity of carcinoembryonic antigen resides in its glycophosphatidyl-inositol anchor". The Journal of Cell Biology. 150 (3): 613–626. doi:10.1083/jcb.150.3.613. PMC 2175204. PMID 10931872.
Bajenova OV, Zimmer R, Stolper E, Salisbury-Rowswell J, Nanji A, Thomas P (August 2001). "Heterogeneous RNA-binding protein M4 is a receptor for carcinoembryonic antigen in Kupffer cells". The Journal of Biological Chemistry. 276 (33): 31067–31073. doi:10.1074/jbc.M104093200. PMID 11406629.
Wirth T, Soeth E, Czubayko F, Juhl H (2002). "Inhibition of endogenous carcinoembryonic antigen (CEA) increases the apoptotic rate of colon cancer cells and inhibits metastatic tumor growth". Clinical & Experimental Metastasis. 19 (2): 155–160. doi:10.1023/A:1014566127493. PMID 11964079. S2CID 3138022.
Louhimo J, Carpelan-Holmström M, Alfthan H, Stenman UH, Järvinen HJ, Haglund C (October 2002). "Serum HCG beta, CA 72-4 and CEA are independent prognostic factors in colorectal cancer". International Journal of Cancer. 101 (6): 545–548. doi:10.1002/ijc.90009. PMID 12237895. S2CID 7030523.
Hampton R, Walker M, Marshall J, Juhl H (November 2002). "Differential expression of carcinoembryonic antigen (CEA) splice variants in whole blood of colon cancer patients and healthy volunteers: implication for the detection of circulating colon cancer cells". Oncogene. 21 (51): 7817–7823. doi:10.1038/sj.onc.1205906. PMID 12420218.

External links

CEACAM5+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Human CEACAM5 genome location and CEACAM5 gene details page in the UCSC Genome Browser.
PDBe-KB provides an overview of all the structure information available in the PDB for Human Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000105388 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-3] "Entrez Gene: CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5".

[4] Beauchemin N, Arabzadeh A (December 2013). "Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) in cancer progression and metastasis". Cancer and Metastasis Reviews. 32 (3–4): 643–671. doi:10.1007/s10555-013-9444-6. PMID 23903773. S2CID 10344352.

[5] Zhang X, Han X, Zuo P, Zhang X, Xu H (September 2020). "CEACAM5 stimulates the progression of non-small-cell lung cancer by promoting cell proliferation and migration". The Journal of International Medical Research. 48 (9) 300060520959478. doi:10.1177/0300060520959478. PMC 7536504. PMID 32993395.

[6] Benchimol S, Fuks A, Jothy S, Beauchemin N, Shirota K, Stanners CP (April 1989). "Carcinoembryonic antigen, a human tumor marker, functions as an intercellular adhesion molecule". Cell. 57 (2): 327–334. doi:10.1016/0092-8674(89)90970-7. PMID 2702691. S2CID 30740594.

[7] Ilantzis C, DeMarte L, Screaton RA, Stanners CP (2002). "Deregulated expression of the human tumor marker CEA and CEA family member CEACAM6 disrupts tissue architecture and blocks colonocyte differentiation". Neoplasia. 4 (2): 151–163. doi:10.1038/sj.neo.7900201. PMC 1550325. PMID 11896570.

[8] Ordoñez C, Screaton RA, Ilantzis C, Stanners CP (July 2000). "Human carcinoembryonic antigen functions as a general inhibitor of anoikis". Cancer Research. 60 (13): 3419–3424. PMID 10910050.

[9] Gisina A, Novikova S, Kim Y, Sidorov D, Bykasov S, Volchenko N, et al. (2021-01-01). "CEACAM5 overexpression is a reliable characteristic of CD133-positive colorectal cancer stem cells". Cancer Biomarkers. 32 (1): 85–98. doi:10.3233/CBM-203187. PMID 34092615. S2CID 235359543.

[10] LaPointe N, Hertle N, Hsu SC, Kellis J, King N, Littrell J, et al. (2021-05-20). "Validation of an immunohistochemical assay, CEACAM5 IHC 769, under development for use with the antibody-drug conjugate tusamitamab ravtansine (SAR408701)". Journal of Clinical Oncology. 39 (15_suppl) e21030. doi:10.1200/JCO.2021.39.15_suppl.e21030. ISSN 0732-183X. S2CID 236398737.

[11] Kim YJ, Li W, Zhelev DV, Mellors JW, Dimitrov DS, Baek DS (2023-02-27). "Chimeric antigen receptor-T cells are effective against CEACAM5 expressing non-small cell lung cancer cells resistant to antibody-drug conjugates". Frontiers in Oncology. 13 1124039. doi:10.3389/fonc.2023.1124039. PMC 10010383. PMID 36923424.

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v t e Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1–50	CD1 a-c 1A 1B 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51–100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101–150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151–200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201–250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249
251–300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301–350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD327 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350
Category Commons

CEACAM5

Functions

See also

References

Further reading

External links