Integrin alpha 11

Integrin alpha-11 is a protein that, in humans, is encoded by the ITGA11 gene. This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein contains an I domain, is expressed in muscle tissue, dimerizes with beta 1 integrin in vitro, and appears to bind collagen in this form. Therefore, the protein may be involved in attaching muscle tissue to the extracellular matrix. Alternative transcriptional splice variants have been found for this gene, but their biological validity is not determined. According to one study, ITGA11 expression is increased in the anterior stroma of corneal buttons excised from the eyes affected by keratoconus. Another study showed that ITGA11 is overexpressed in myofibroblasts in different human fibrotic diseases, including liver cirrhosis, renal fibrosis, and lung fibrosis tissues. ITGA11 has also been found to be upregulated in the tumor stroma of pancreatic ductal adenocarcinoma. Knocking down of ITGA11 in human pancreatic stellate cells led to the inhibition of their differentiation into myofibroblasts and paracrine effect on tumor cells.

Protein-coding gene in the species Homo sapiens

ITGA11
Identifiers
Aliases	ITGA11, HsT18964, integrin subunit alpha 11
External IDs	OMIM: 604042, 604789; MGI: 2442114; HomoloGene: 8151; GeneCards: ITGA11; OMA:ITGA11 - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q23 Start 68,296,532 bp[1] End 68,432,163 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 B Start 62,585,108 bp[2] End 62,691,264 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Descending thoracic aorta ascending aorta Achilles tendon stromal cell of endometrium body of uterus right coronary artery smooth muscle tissue myometrium left coronary artery popliteal artery Top expressed in upper arm appendicular skeleton mesenchyme rib bones of pectoral girdle second toe humerus clavicle mandible quadriceps femoris muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function collagen receptor activity collagen binding involved in cell-matrix adhesion collagen binding metal ion binding Cellular component integral component of membrane integrin complex plasma membrane integrin alpha11-beta1 complex membrane focal adhesion Biological process integrin-mediated signaling pathway muscle organ development cell adhesion cell-matrix adhesion extracellular matrix organization cell adhesion mediated by integrin osteoblast differentiation substrate-dependent cell migration collagen-activated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 22801 319480 Ensembl ENSG00000137809 ENSMUSG00000032243 UniProt Q9UKX5 P61622 RefSeq (mRNA) NM_001004439 NM_012211 NM_176922 RefSeq (protein) NP_001004439 n/a Location (UCSC) Chr 15: 68.3 – 68.43 Mb Chr 9: 62.59 – 62.69 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Integrin alpha-11 is a protein that, in humans, is encoded by the ITGA11 gene.^[5][6]

This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein contains an I domain, is expressed in muscle tissue, dimerizes with beta 1 integrin in vitro, and appears to bind collagen in this form. Therefore, the protein may be involved in attaching muscle tissue to the extracellular matrix. Alternative transcriptional splice variants have been found for this gene, but their biological validity is not determined.^[6]

According to one study, ITGA11 expression is increased in the anterior stroma of corneal buttons excised from the eyes affected by keratoconus.^[7] Another study showed that ITGA11 is overexpressed in myofibroblasts in different human fibrotic diseases, including liver cirrhosis, renal fibrosis, and lung fibrosis tissues.^[8] ITGA11 has also been found to be upregulated in the tumor stroma of pancreatic ductal adenocarcinoma. ^[9] Knocking down of ITGA11 in human pancreatic stellate cells led to the inhibition of their differentiation into myofibroblasts and paracrine effect on tumor cells. ^[9]

References

[edit]

1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000137809 – Ensembl, May 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000032243 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Lehnert K, Ni J, Leung E, Gough SM, Weaver A, Yao WP, et al. (September 1999). "Cloning, sequence analysis, and chromosomal localization of the novel human integrin alpha11 subunit (ITGA11)". Genomics. 60 (2): 179–187. doi:10.1006/geno.1999.5909. PMID 10486209.
6. ^ ^{a b} "Entrez Gene: ITGA11 integrin, alpha 11".
7. ^ Byström B, Carracedo S, Behndig A, Gullberg D, Pedrosa-Domellöf F (November 2009). "Alpha11 integrin in the human cornea: importance in development and disease". Investigative Ophthalmology & Visual Science. 50 (11): 5044–5053. doi:10.1167/iovs.08-3261. PMID 19516006.
8. ^ Bansal R, Nakagawa S, Yazdani S, van Baarlen J, Venkatesh A, Koh AP, et al. (November 2017). "Integrin alpha 11 in the regulation of the myofibroblast phenotype: implications for fibrotic diseases". Experimental & Molecular Medicine. 49 (11): e396. doi:10.1038/emm.2017.213. PMC 5704196. PMID 29147013.
9. ^ ^{a b} Schnittert J, Bansal R, Mardhian DF, van Baarlen J, Östman A, Prakash J (May 2019). "Integrin α11 in pancreatic stellate cells regulates tumor stroma interaction in pancreatic cancer". FASEB Journal. 33 (5): 6609–6621. doi:10.1096/fj.201802336R. PMID 30808244. S2CID 73482848.

Further reading

[edit]

• Zhu CQ, Popova SN, Brown ER, Barsyte-Lovejoy D, Navab R, Shih W, et al. (July 2007). "Integrin alpha 11 regulates IGF2 expression in fibroblasts to enhance tumorigenicity of human non-small-cell lung cancer cells". Proceedings of the National Academy of Sciences of the United States of America. 104 (28): 11754–11759. Bibcode:2007PNAS..10411754Z. doi:10.1073/pnas.0703040104. PMC 1913903. PMID 17600088.
• Leomil Coelho LF, Mota BE, Sales PC, Marques JT, de Oliveira JG, Bonjardim CA, et al. (March 2006). "Integrin alpha 11 is a novel type I interferon stimulated gene". Cytokine. 33 (6): 352–361. doi:10.1016/j.cyto.2006.03.007. PMID 16697656.
• Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, et al. (June 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology. 22 (6): 707–716. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
• Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, et al. (January 2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nature Genetics. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
• Zhang WM, Kapyla J, Puranen JS, Knight CG, Tiger CF, Pentikainen OT, et al. (February 2003). "alpha 11beta 1 integrin recognizes the GFOGER sequence in interstitial collagens". The Journal of Biological Chemistry. 278 (9): 7270–7277. doi:10.1074/jbc.M210313200. PMID 12496264.
• Zhang WM, Popova SN, Bergman C, Velling T, Gullberg MK, Gullberg D (October 2002). "Analysis of the human integrin alpha11 gene (ITGA11) and its promoter". Matrix Biology. 21 (6): 513–523. doi:10.1016/S0945-053X(02)00054-9. PMID 12392762.
• Tiger CF, Fougerousse F, Grundström G, Velling T, Gullberg D (September 2001). "alpha11beta1 integrin is a receptor for interstitial collagens involved in cell migration and collagen reorganization on mesenchymal nonmuscle cells". Developmental Biology. 237 (1): 116–129. doi:10.1006/dbio.2001.0363. PMID 11518510. S2CID 52235811.
• Velling T, Kusche-Gullberg M, Sejersen T, Gullberg D (September 1999). "cDNA cloning and chromosomal localization of human alpha(11) integrin. A collagen-binding, I domain-containing, beta(1)-associated integrin alpha-chain present in muscle tissues". The Journal of Biological Chemistry. 274 (36): 25735–25742. doi:10.1074/jbc.274.36.25735. PMID 10464311.

External links

[edit]

• "ITGA11 Orthologs". Cell Migration Gateway. Cell Migration Consortium. Retrieved 2021-04-30.{{cite web}}: CS1 maint: deprecated archival service (link)

This article on a gene on human chromosome 15 is a stub. You can help Wikipedia by adding missing information.

• v
• t
• e