CD81

CD81
Uygun yapılar
PDB	Ortolog araması: PDBe RCSB
PDB kimlik kodlarının listesi
	1G8Q, 1IV5, 3X0E, 5DFW, 5DFV
Tanımlayıcılar
Başka adlar	CD81
Dış kimlikler	OMIM: 186845 MGI: 1096398 HomoloGene: 20915 GeneCards: CD81
Gen yerleşimi (İnsan)
Krom.	11. Kromozom (insan)
Bitiş	2,397,397 bç
RNA ekspresyonu deseni
	Daha çok ekspresyon verisi başvurusu
Gen ontolojisi
Moleküler işlevi	• GO:0001948, GO:0016582 protein bağlanması; • MHC class II protein complex binding; • transferrin receptor binding; • virus receptor activity; • integrin binding; • cholesterol binding; • lipid binding;
Hücresel bileşeni	• integral component of membrane; • Vezikül; • membrane; • fokal adezyon; • integral component of plasma membrane; • immunological synapse; • extracellular exosome; • Hücre zarı; • basolateral plasma membrane;
Biyolojik süreci	• positive regulation of 1-phosphatidylinositol 4-kinase activity; • GO:0034613 protein localization; • regulation of protein stability; • receptor internalization; • cellular response to low-density lipoprotein particle stimulus; • regulation of cell motility; • receptor-mediated virion attachment to host cell; • protein localization to lysosome; • cell surface receptor signaling pathway; • positive regulation of B cell proliferation; • positive regulation of cell population proliferation; • regulation of immune response; • positive regulation of peptidyl-tyrosine phosphorylation; • Viral giriş; • positive regulation of protein catabolic process in the vacuole; • cell population proliferation; • GO:0022415 viral process; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • regulation of complement activation; • humoral immune response mediated by circulating immunoglobulin; • protein localization to plasma membrane; • adaptive immune response; • immune system process;
	Kaynaklar:Amigo / QuickGO
Ortologlar
	975
	12520
	ENSG00000110651
	ENSMUSG00000037706
	P60033
	P35762
	NM_001297649; NM_004356
	NM_133655
	NP_001284578; NP_004347
	NP_598416
	Vikiveri
İnsan'ı Gör/Düzenle	Fare'yi Gör/Düzenle

CD81 molekülü, ayrıca 81. Başkalaşım Kümesi olarak da bilinir, insanların 11. kromozomunda yer alan CD81 geni tarafından kodlanan bir proteindir.^[4]^[5]

Kaynakça

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000110651 - Ensembl, May 2017
^ "İnsan PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Fare PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: CD81 CD81 molecule". 13 Nisan 2010 tarihinde kaynağından arşivlendi. Erişim tarihi: 11 Şubat 2024.
^ Andria ML, Hsieh CL, Oren R, Francke U, Levy S (August 1991). "Genomic organization and chromosomal localization of the TAPA-1 gene". Journal of Immunology. 147 (3). ss. 1030-6. doi:10.4049/jimmunol.147.3.1030. PMID 1650385. 5 Eylül 2004 tarihinde kaynağından arşivlendi11 Şubat 2024.

Ek okuma

Berditchevski F (2002). "Complexes of tetraspanins with integrins: more than meets the eye". J. Cell Sci. 114 (Pt 23). ss. 4143-51. doi:10.1242/jcs.114.23.4143. PMID 11739647.
Ye J (2007). "Reliance of Host Cholesterol Metabolic Pathways for the Life Cycle of Hepatitis C Virus". PLOS Pathog. 3 (8). ss. e108. doi:10.1371/journal.ppat.0030108. PMC 1959368 . PMID 17784784.
Bradbury LE, Kansas GS, Levy S, ve diğerleri. (1992). "The CD19/CD21 signal transducing complex of human B lymphocytes includes the target of antiproliferative antibody-1 and Leu-13 molecules". J. Immunol. 149 (9). ss. 2841-50. doi:10.4049/jimmunol.149.9.2841. PMID 1383329.
Andria ML, Hsieh CL, Oren R, ve diğerleri. (1991). "Genomic organization and chromosomal localization of the TAPA-1 gene". J. Immunol. 147 (3). ss. 1030-6. doi:10.4049/jimmunol.147.3.1030. PMID 1650385.
Oren R, Takahashi S, Doss C, ve diğerleri. (1990). "TAPA-1, the target of an antiproliferative antibody, defines a new family of transmembrane proteins". Mol. Cell. Biol. 10 (8). ss. 4007-15. doi:10.1128/MCB.10.8.4007. PMC 360911 . PMID 1695320.
Levy S, Nguyen VQ, Andria ML, Takahashi S (1991). "Structure and membrane topology of TAPA-1". J. Biol. Chem. 266 (22). ss. 14597-602. doi:10.1016/S0021-9258(18)98728-4. PMID 1860863.
Takahashi S, Doss C, Levy S, Levy R (1990). "TAPA-1, the target of an antiproliferative antibody, is associated on the cell surface with the Leu-13 antigen". J. Immunol. 145 (7). ss. 2207-13. doi:10.4049/jimmunol.145.7.2207. PMID 2398277.
Matsumoto AK, Martin DR, Carter RH, ve diğerleri. (1993). "Functional dissection of the CD21/CD19/TAPA-1/Leu-13 complex of B lymphocytes". J. Exp. Med. 178 (4). ss. 1407-17. doi:10.1084/jem.178.4.1407. PMC 2191213 . PMID 7690834.
Nagira M, Imai T, Ishikawa I, ve diğerleri. (1994). "Mouse homologue of C33 antigen (CD82), a member of the transmembrane 4 superfamily: complementary DNA, genomic structure, and expression". Cell. Immunol. 157 (1). ss. 144-57. doi:10.1006/cimm.1994.1212. PMID 8039242.
Virtaneva KI, Emi N, Marken JS, ve diğerleri. (1994). "Chromosomal localization of three human genes coding for A15, L6, and S5.7 (TAPA1): all members of the transmembrane 4 superfamily of proteins". Immunogenetics. 39 (5). ss. 329-34. doi:10.1007/BF00189229. PMID 8168850.
Radford KJ, Thorne RF, Hersey P (1996). "CD63 associates with transmembrane 4 superfamily members, CD9 and CD81, and with beta 1 integrins in human melanoma". Biochem. Biophys. Res. Commun. 222 (1). ss. 13-8. doi:10.1006/bbrc.1996.0690. PMID 8630057.
Szöllósi J, Horejsí V, Bene L, ve diğerleri. (1996). "Supramolecular complexes of MHC class I, MHC class II, CD20, and tetraspan molecules (CD53, CD81, and CD82) at the surface of a B cell line JY". J. Immunol. 157 (7). ss. 2939-46. doi:10.4049/jimmunol.157.7.2939. PMID 8816400.
Berditchevski F, Tolias KF, Wong K, ve diğerleri. (1997). "A novel link between integrins, transmembrane-4 superfamily proteins (CD63 and CD81), and phosphatidylinositol 4-kinase". J. Biol. Chem. 272 (5). ss. 2595-8. doi:10.1074/jbc.272.5.2595. PMID 9006891.
Berditchevski F, Chang S, Bodorova J, Hemler ME (1997). "Generation of monoclonal antibodies to integrin-associated proteins. Evidence that alpha3beta1 complexes with EMMPRIN/basigin/OX47/M6". J. Biol. Chem. 272 (46). ss. 29174-80. doi:10.1074/jbc.272.46.29174. PMID 9360995.
Tachibana I, Bodorova J, Berditchevski F, ve diğerleri. (1997). "NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins". J. Biol. Chem. 272 (46). ss. 29181-9. doi:10.1074/jbc.272.46.29181. PMID 9360996.
Hu RJ, Lee MP, Connors TD, ve diğerleri. (1998). "A 2.5-Mb transcript map of a tumor-suppressing subchromosomal transferable fragment from 11p15.5, and isolation and sequence analysis of three novel genes". Genomics. 46 (1). ss. 9-17. doi:10.1006/geno.1997.4981. PMID 9403053.
Pileri P, Uematsu Y, Campagnoli S, ve diğerleri. (1998). "Binding of hepatitis C virus to CD81". Science. 282 (5390). ss. 938-41. Bibcode:1998Sci...282..938P. doi:10.1126/science.282.5390.938. PMID 9794763.
Serru V, Le Naour F, Billard M, ve diğerleri. (1999). "Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions". Biochem. J. 340 (Pt 1). ss. 103-11. doi:10.1042/0264-6021:3400103. PMC 1220227 . PMID 10229664.
Tachibana I, Hemler ME (1999). "Role of Transmembrane 4 Superfamily (Tm4sf) Proteins Cd9 and Cd81 in Muscle Cell Fusion and Myotube Maintenance". J. Cell Biol. 146 (4). ss. 893-904. doi:10.1083/jcb.146.4.893. PMC 2156130 . PMID 10459022.
Higginbottom A, Quinn ER, Kuo CC, ve diğerleri. (2000). "Identification of Amino Acid Residues in CD81 Critical for Interaction with Hepatitis C Virus Envelope Glycoprotein E2". J. Virol. 74 (8). ss. 3642-9. doi:10.1128/JVI.74.8.3642-3649.2000. PMC 111874 . PMID 10729140.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000110651 - Ensembl, May 2017

[2] "İnsan PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Fare PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-4] "Entrez Gene: CD81 CD81 molecule". 13 Nisan 2010 tarihinde kaynağından arşivlendi. Erişim tarihi: 11 Şubat 2024.

[pmid1650385-5] Andria ML, Hsieh CL, Oren R, Francke U, Levy S (August 1991). "Genomic organization and chromosomal localization of the TAPA-1 gene". Journal of Immunology. 147 (3). ss. 1030-6. doi:10.4049/jimmunol.147.3.1030. PMID 1650385. 5 Eylül 2004 tarihinde kaynağından arşivlendi11 Şubat 2024.

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g t d Proteinler: Başkalaşım kümeleri
1-50	CD1 1A 1B 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51-100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101-150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151-200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201-250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249
251-300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301-350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD327 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350