POLR2L

POLR2L
Estruturas disponíveis
PDB	Pesquisa Human UniProt: PDBe RCSB
Lista de códigos id do PDB
	5FLM, 5IYD, 5IYC, 5IY8, 5IYA, 5IYB, 5IY6, 5IY9, 5IY7
Identificadores
Nomes alternativos	POLR2L
IDs externos	OMIM: 601189 HomoloGene: 129854 GeneCards: POLR2L
Ontologia genética
Função molecular	• DNA binding; • zinc ion binding; • RNA polymerase II activity; • metal ion binding; • RNA polymerase III activity; • DNA-directed 5'-3' RNA polymerase activity; • GO:0001948, GO:0016582 ligação a proteínas plasmáticas; • RNA polymerase I activity;
Componente celular	• citosol; • cariolinfa; • RNA polymerase I complex; • RNA polymerase III complex; • RNA polimerase II; • núcleo celular;
Processo biológico	• termination of RNA polymerase I transcription; • mRNA splicing, via spliceosome; • epigenetic maintenance of chromatin in transcription-competent conformation; • regulation of transcription by RNA polymerase I; • transcription initiation from RNA polymerase I promoter; • transcription elongation from RNA polymerase II promoter; • 7-methylguanosine mRNA capping; • transcription by RNA polymerase II; • transcription-coupled nucleotide-excision repair; • transcription initiation from RNA polymerase II promoter; • fibroblast growth factor receptor signaling pathway; • transcription by RNA polymerase III; • snRNA transcription by RNA polymerase II; • RNA metabolic process; • GO:1905616 regulation of gene silencing by miRNA; • transcription, DNA-templated; • GO:0001183 transcription elongation from RNA polymerase I promoter; • positive regulation of type I interferon production; • somatic stem cell population maintenance; • positive regulation of viral transcription;
	Sources:Amigo / QuickGO
Padrão de expressão RNA
	; ;
	Mais dados de referência de expressão
Ortólogos
	5441
	n/a
	ENSG00000177700
	n/a
	P62875
	n/a
	NM_021128
	n/a
	NP_066951
	n/a
	Wikidata
Ver/Editar Humano

As subunidades RPABC5 das polimerases I, II e III do RNA dirigidas pelo DNA são proteínas que, em humanos, são codificadas pelo gene POLR2L.^[2]

Função

Este gene codifica uma subunidade da polimerase II do RNA, a polimerase responsável pela síntese do RNA mensageiro em eucariotos. O produto deste gene contém quatro cisteínas conservadas características de um domínio atípico de ligação ao zinco. Como sua contraparte na levedura, esta subunidade pode ser compartilhada pelas outras duas polimerases do RNA dirigidas pelo DNA.^[3]

Interações

Foi demonstrado que POLR2L interage com POLR2C,^[4] POLR2A,^[4] POLR2B^[4] e POLR2E.^[4]

Referências

↑ «Human PubMed Reference:»
↑ Acker J, Murroni O, Mattei MG, Kedinger C, Vigneron M (setembro de 1996). «The gene (POLR2L) encoding the hRPB7.6 subunit of human RNA polymerase». Genomics. 32 (1): 86–90. PMID 8786124. doi:10.1006/geno.1996.0079
↑ «Entrez Gene: POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa»
↑ ^a ^b ^c ^d Acker J, de Graaff M, Cheynel I, Khazak V, Kedinger C, Vigneron M (julho de 1997). «Interactions between the human RNA polymerase II subunits». J. Biol. Chem. 272 (27): 16815–21. PMID 9201987. doi:10.1074/jbc.272.27.16815

Bibliografia

Jeang KT (1998). «Tat, Tat-associated kinase, and transcription.». J. Biomed. Sci. 5 (1): 24–7. PMID 9570510. doi:10.1007/BF02253352
Yankulov K, Bentley D (1998). «Transcriptional control: Tat cofactors and transcriptional elongation.». Curr. Biol. 8 (13): R447–9. PMID 9651670. doi:10.1016/S0960-9822(98)70289-1
Romano G, Kasten M, De Falco G, Micheli P, Khalili K, Giordano A (2000). «Regulatory functions of Cdk9 and of cyclin T1 in HIV tat transactivation pathway gene expression». J. Cell. Biochem. 75 (3): 357–68. PMID 10536359. doi:10.1002/(SICI)1097-4644(19991201)75:3<357::AID-JCB1>3.0.CO;2-K
Marcello A, Zoppé M, Giacca M (2002). «Multiple modes of transcriptional regulation by the HIV-1 Tat transactivator». IUBMB Life. 51 (3): 175–81. PMID 11547919. doi:10.1080/152165401753544241
Stevens M, De Clercq E, Balzarini J (2007). «The regulation of HIV-1 transcription: molecular targets for chemotherapeutic intervention». Med Res Rev. 26 (5): 595–625. PMC 7168390. PMID 16838299. doi:10.1002/med.20081
Harrich D, McMillan N, Munoz L, Apolloni A, Meredith L (2007). «Will diverse Tat interactions lead to novel antiretroviral drug targets?». Current Drug Targets. 7 (12): 1595–606. PMID 17168834. doi:10.2174/138945006779025338
Jang KL, Collins MK, Latchman DS (1992). «The human immunodeficiency virus tat protein increases the transcription of human Alu repeated sequences by increasing the activity of the cellular transcription factor TFIIIC». J. Acquir. Immune Defic. Syndr. 5 (11): 1142–7. PMID 1403646
Kato H, Sumimoto H, Pognonec P, Chen CH, Rosen CA, Roeder RG (1992). «HIV-1 Tat acts as a processivity factor in vitro in conjunction with cellular elongation factors». Genes Dev. 6 (4): 655–66. PMID 1559613. doi:10.1101/gad.6.4.655
Southgate C, Zapp ML, Green MR (1990). «Activation of transcription by HIV-1 Tat protein tethered to nascent RNA through another protein». Nature. 345 (6276): 640–2. Bibcode:1990Natur.345..640S. PMID 2190099. doi:10.1038/345640a0
Wu-Baer F, Sigman D, Gaynor RB (1995). «Specific binding of RNA polymerase II to the human immunodeficiency virus trans-activating region RNA is regulated by cellular cofactors and Tat». Proc. Natl. Acad. Sci. U.S.A. 92 (16): 7153–7. Bibcode:1995PNAS...92.7153W. PMC 41297. PMID 7638159. doi:10.1073/pnas.92.16.7153
Shpakovski GV, Acker J, Wintzerith M, Lacroix JF, Thuriaux P, Vigneron M (1995). «Four subunits that are shared by the three classes of RNA polymerase are functionally interchangeable between Homo sapiens and Saccharomyces cerevisiae». Mol. Cell. Biol. 15 (9): 4702–10. PMC 230713. PMID 7651387. doi:10.1128/mcb.15.9.4702
Herrmann CH, Rice AP (1995). «Lentivirus Tat proteins specifically associate with a cellular protein kinase, TAK, that hyperphosphorylates the carboxyl-terminal domain of the large subunit of RNA polymerase II: candidate for a Tat cofactor». J. Virol. 69 (3): 1612–20. PMC 188757. PMID 7853496. doi:10.1128/JVI.69.3.1612-1620.1995
McKune K, Moore PA, Hull MW, Woychik NA (1996). «Six human RNA polymerase subunits functionally substitute for their yeast counterparts». Mol. Cell. Biol. 15 (12): 6895–900. PMC 230944. PMID 8524256. doi:10.1128/mcb.15.12.6895
Keen NJ, Gait MJ, Karn J (1996). «Human immunodeficiency virus type-1 Tat is an integral component of the activated transcription-elongation complex». Proc. Natl. Acad. Sci. U.S.A. 93 (6): 2505–10. Bibcode:1996PNAS...93.2505K. PMC 39827. PMID 8637904. doi:10.1073/pnas.93.6.2505
Yang X, Herrmann CH, Rice AP (1996). «The human immunodeficiency virus Tat proteins specifically associate with TAK in vivo and require the carboxyl-terminal domain of RNA polymerase II for function». J. Virol. 70 (7): 4576–84. PMC 190394. PMID 8676484. doi:10.1128/JVI.70.7.4576-4584.1996
Agostini I, Navarro JM, Rey F, Bouhamdan M, Spire B, Vigne R, Sire J (1996). «The human immunodeficiency virus type 1 Vpr transactivator: cooperation with promoter-bound activator domains and binding to TFIIB». J. Mol. Biol. 261 (5): 599–606. PMID 8800208. doi:10.1006/jmbi.1996.0485
Zhou Q, Sharp PA (1996). «Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat». Science. 274 (5287): 605–10. Bibcode:1996Sci...274..605Z. PMID 8849451. doi:10.1126/science.274.5287.605
Okamoto H, Sheline CT, Corden JL, Jones KA, Peterlin BM (1996). «Trans-activation by human immunodeficiency virus Tat protein requires the C-terminal domain of RNA polymerase II». Proc. Natl. Acad. Sci. U.S.A. 93 (21): 11575–9. Bibcode:1996PNAS...9311575O. PMC 38099. PMID 8876177. doi:10.1073/pnas.93.21.11575
Chun RF, Jeang KT (1996). «Requirements for RNA polymerase II carboxyl-terminal domain for activated transcription of human retroviruses human T-cell lymphotropic virus I and HIV-1». J. Biol. Chem. 271 (44): 27888–94. PMID 8910388. doi:10.1074/jbc.271.44.27888

[1] «Human PubMed Reference:»

[pmid8786124-2] Acker J, Murroni O, Mattei MG, Kedinger C, Vigneron M (setembro de 1996). «The gene (POLR2L) encoding the hRPB7.6 subunit of human RNA polymerase». Genomics. 32 (1): 86–90. PMID 8786124. doi:10.1006/geno.1996.0079

[3] «Entrez Gene: POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa»

[pmid9201987-4] Acker J, de Graaff M, Cheynel I, Khazak V, Kedinger C, Vigneron M (julho de 1997). «Interactions between the human RNA polymerase II subunits». J. Biol. Chem. 272 (27): 16815–21. PMID 9201987. doi:10.1074/jbc.272.27.16815

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