SLIT2

SLIT2
Estructuras disponibles
PDB	Búsqueda ortóloga: H0Y9Z6 PDBe H0Y9Z6 RCSB
Lista de codigos id de PDB
	2V70, 2V9S, 2V9T, 2WFH
Identificadores
Alias	SLIT2, SLIL3, Slit-2, slit guidance ligand 2
IDs externos	OMIM: 603746 MGI: 1315205 HomoloGene: 3516 GeneCards: SLIT2
Ontología génica
Función molecular	• calcium ion binding; • heparin binding; • protein homodimerization activity; • GTPase inhibitor activity; • laminin-1 binding; • GO:0001948, GO:0016582 unión a proteína plasmática; • identical protein binding; • Roundabout binding; • proteoglycan binding;
Componente celular	• citoplasma; • membrana; • región extracelular; • cell surface; • Exosoma (vesícula); • membrana plasmática; • extracelular;
Proceso biológico	• GO:0033128 negative regulation of protein phosphorylation; • negative regulation of chemokine-mediated signaling pathway; • negative regulation of neutrophil chemotaxis; • negative regulation of cellular response to growth factor stimulus; • chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration; • diferenciación celular; • ureteric bud development; • negative chemotaxis; • negative regulation of actin filament polymerization; • negative regulation of small GTPase mediated signal transduction; • negative regulation of retinal ganglion cell axon guidance; • negative regulation of mononuclear cell migration; • corticospinal neuron axon guidance through spinal cord; • negative regulation of smooth muscle cell migration; • Roundabout signaling pathway; • positive regulation of axonogenesis; • desarrollo neural; • cell migration involved in sprouting angiogenesis; • negative regulation of endothelial cell migration; • Guía de axón; • desarrollo de organismo multicelular; • quimiotaxis; • negative regulation of smooth muscle cell chemotaxis; • cellular response to hormone stimulus; • negative regulation of cell migration; • negative regulation of monocyte chemotaxis; • negative regulation of cell growth; • response to cortisol; • apoptotic process involved in luteolysis; • positive regulation of apoptotic process; • induction of negative chemotaxis; • cellular response to heparin; • motor neuron axon guidance; • branching morphogenesis of an epithelial tube; • negative regulation of leukocyte chemotaxis; • chemorepulsion involved in postnatal olfactory bulb interneuron migration; • axon extension involved in axon guidance; • negative regulation of lamellipodium assembly; • negative regulation of vascular permeability; • retinal ganglion cell axon guidance; • GO:0034259 negative regulation of GTPase activity; • aortic valve morphogenesis; • pulmonary valve morphogenesis; • ventricular septum morphogenesis;
	Fuentes: Amigo / QuickGO
Patrón de la expressión del ARN
	Más referencias a datos de expressión
Ortólogos
	9353
	20563
	ENSG00000145147
	ENSMUSG00000031558
	O94813
	Q9R1B9
	NM_001289135; NM_001289136; NM_004787
	NM_001291227; NM_001291228; NM_178804
	NP_001276064; NP_001276065; NP_004778
	NP_001278156; NP_001278157; NP_848919
	Wikidata
Ver/Editar Humano	Ver/Editar Ratón

El ligando de guía de rendija 2 (proteína homóloga Slit 2) es una proteína que en humanos está codificada por el gen SLIT2.^[3]^[4]^[5]

Este gen codifica una glicoproteínas grande de la matriz extracelular (ECM) de aproximadamente 200 kD.

Slit se sintetiza en el sistema nervioso central de la mosca, por las células de la glía de la línea media.

Existen tres genes slit (slit1, slit2, slit3) en mamíferos.^[4]

Interacciones

Se ha demostrado que SLIT2 interactúa con Glypican 1.^[6]

Referencias

↑ «Human PubMed Reference:».
↑ «Mouse PubMed Reference:».
↑ Itoh A; Miyabayashi T; Ohno M; Sakano S (February 1999). «Cloning and expressions of three mammalian homologues of Drosophila slit suggest possible roles for Slit in the formation and maintenance of the nervous system». Brain Res Mol Brain Res 62 (2): 175-86. PMID 9813312. doi:10.1016/S0169-328X(98)00224-1.
↑ ^a ^b Chedotal A (February 2008). «Slits and their receptors». Adv Exp Med Biol. Advances in Experimental Medicine and Biology 621: 65-80. ISBN 978-0-387-76714-7. PMID 18269211. doi:10.1007/978-0-387-76715-4_5.
↑ «Entrez Gene: SLIT2 slit homolog 2 (Drosophila)».
↑ Ronca, F; Andersen J S; Paech V; Margolis R U (August 2001). «Characterization of Slit protein interactions with glypican-1». J. Biol. Chem. (United States) 276 (31): 29141-7. ISSN 0021-9258. PMID 11375980. doi:10.1074/jbc.M100240200.

Enlaces externos

En HomoloGene: SLIT2

En Genome:SLIT2
En MalaCards.Enfermedades que coinciden con:SLIT2
En Estudio de asociación del genoma completo (GWAS) SLIT2
En GeneCards SLIT2

Datos: Q18034022

[1] «Human PubMed Reference:».

[2] «Mouse PubMed Reference:».

[pmid9813312-3] Itoh A; Miyabayashi T; Ohno M; Sakano S (February 1999). «Cloning and expressions of three mammalian homologues of Drosophila slit suggest possible roles for Slit in the formation and maintenance of the nervous system». Brain Res Mol Brain Res 62 (2): 175-86. PMID 9813312. doi:10.1016/S0169-328X(98)00224-1.

[pmid18269211-4] Chedotal A (February 2008). «Slits and their receptors». Adv Exp Med Biol. Advances in Experimental Medicine and Biology 621: 65-80. ISBN 978-0-387-76714-7. PMID 18269211. doi:10.1007/978-0-387-76715-4_5.

[entrez-5] «Entrez Gene: SLIT2 slit homolog 2 (Drosophila)».

[pmid11375980-6] Ronca, F; Andersen J S; Paech V; Margolis R U (August 2001). «Characterization of Slit protein interactions with glypican-1». J. Biol. Chem. (United States) 276 (31): 29141-7. ISSN 0021-9258. PMID 11375980. doi:10.1074/jbc.M100240200.

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