UTF1

Undifferentiated embryonic cell transcription factor 1 is a protein in humans that is encoded by the UTF1 gene. UTF1, first reported in 1998, is expressed in pluripotent cells including embryonic stem cells and embryonic carcinoma cells. Its expression is rapidly reduced upon differentiation. UTF1 protein is localized to the cell nucleus, where it functions to regulate the pluripotent chromatin state and buffer mRNA levels by promoting degradation of mRNA. Aberrant expression of UTF1 has also been reported in cervical cancer cells, where the UTF1 gene promoter loses methylation and becomes abnormally expressed compared to normal cervical cells. In rat testis, UTF1 expression is limited to a subpopulation of early type A spermatogonia. Further, in adult human testis, UTF1 gene and protein expression has been shown to be restricted to the earliest state of spermatogonium.

Protein-coding gene in the species Homo sapiens

UTF1
Identifiers
Aliases	UTF1, undifferentiated embryonic cell transcription factor 1
External IDs	OMIM: 604130; MGI: 1276125; HomoloGene: 48226; GeneCards: UTF1; OMA:UTF1 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q26.3 Start 133,230,217 bp[1] End 133,231,558 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F4 Start 139,523,702 bp[2] End 139,525,025 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad testicle right testis left testis granulocyte monocyte skin of thigh right uterine tube blood ovary Top expressed in embryo epiblast Gonadal ridge chorion blastocyst embryo morula yolk sac placenta inner cell mass More reference expression data BioGPS n/a
Gene ontology Molecular function transcription coactivator activity HMG box domain binding protein binding Cellular component nucleus Biological process regulation of transcription by RNA polymerase II male gonad development regulation of transcription, DNA-templated transcription, DNA-templated positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8433 22286 Ensembl ENSG00000171794 ENSMUSG00000047751 UniProt Q5T230 Q6J1H4 RefSeq (mRNA) NM_003577 NM_009482 RefSeq (protein) NP_003568 NP_033508 Location (UCSC) Chr 10: 133.23 – 133.23 Mb Chr 7: 139.52 – 139.53 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Undifferentiated embryonic cell transcription factor 1 is a protein in humans that is encoded by the UTF1 gene. ^[5] UTF1, first reported in 1998, is expressed in pluripotent cells including embryonic stem cells and embryonic carcinoma cells.^[6] Its expression is rapidly reduced upon differentiation. UTF1 protein is localized to the cell nucleus, where it functions to regulate the pluripotent chromatin state and buffer mRNA levels by promoting degradation of mRNA.^[7]

Aberrant expression of UTF1 has also been reported in cervical cancer cells, where the UTF1 gene promoter loses methylation and becomes abnormally expressed compared to normal cervical cells.^[8]

In rat testis, UTF1 expression is limited to a subpopulation of early type A spermatogonia.^[9] Further, in adult human testis, UTF1 gene and protein expression has been shown to be restricted to the earliest state of spermatogonium.^[10]

References

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1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000171794 – Ensembl, May 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000047751 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ "Entrez Gene: Undifferentiated embryonic cell transcription factor 1". Retrieved 2013-05-30.
6. ^ Okuda A, Fukushima A, Nishimoto M, Orimo A, Yamagishi T, Nabeshima Y, et al. (April 1998). "UTF1, a novel transcriptional coactivator expressed in pluripotent embryonic stem cells and extra-embryonic cells". The EMBO Journal. 17 (7): 2019–2032. doi:10.1093/emboj/17.7.2019. PMC 1170547. PMID 9524124.
7. ^ Jia J, Zheng X, Hu G, Cui K, Zhang J, Zhang A, et al. (October 2012). "Regulation of pluripotency and self- renewal of ESCs through epigenetic-threshold modulation and mRNA pruning". Cell. 151 (3): 576–589. doi:10.1016/j.cell.2012.09.023. PMC 3575637. PMID 23101626.
8. ^ Guenin S, Mouallif M, Deplus R, Lampe X, Krusy N, Calonne E, et al. (August 2012). "Aberrant promoter methylation and expression of UTF1 during cervical carcinogenesis". PLOS ONE. 7 (8) e42704. Bibcode:2012PLoSO...742704G. doi:10.1371/journal.pone.0042704. PMC 3411846. PMID 22880087.
9. ^ von Kopylow K, Spiess AN (December 2017). "Human spermatogonial markers". Stem Cell Research. 25: 300–309. doi:10.1016/j.scr.2017.11.011. PMID 29239848.
10. ^ Guo J, Grow EJ, Mlcochova H, Maher GJ, Lindskog C, Nie X, et al. (December 2018). "The adult human testis transcriptional cell atlas". Cell Research. 28 (12): 1141–1157. doi:10.1038/s41422-018-0099-2. PMC 6274646. PMID 30315278.

Further reading

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