Propargite

Propargite (IUPAC name 2-(4-tert-butylphenoxy)cyclohexyl prop-2-yne-1-sulfonate, trade names Mitex, Omite and Comite) is a pesticide used to kill mites (an acaricide). It acts through inhibition of mitochondrial ATP synthase, and is in IRAC group 12C. Symptoms of excessive exposure are eye and skin irritation, and possibly sensitization. It is highly toxic to amphibians, fish, and zooplankton, as well as having potential carcinogenity.

Propargite^[1][2]

Names
IUPAC name 2-(4-tert-butylphenoxy)cyclohexyl prop-2-yne-1-sulfonate
Other names Omite, Comite, Uniroyal D014
Identifiers
CAS Number	2312-35-8 Y
3D model (JSmol)	Interactive image
ChEMBL	ChEMBL1416084
ChemSpider	4767
ECHA InfoCard	100.017.279
KEGG	C18602 Y
PubChem CID	4936
UNII	30M429ANKL Y
CompTox Dashboard (EPA)	DTXSID4024276
InChI InChI=1S/C19H26O4S/c1-5-14-21-24(20)23-18-9-7-6-8-17(18)22-16-12-10-15(11-13-16)19(2,3)4/h1,10-13,17-18H,6-9,14H2,2-4H3
SMILES O=S(OCC#C)OC2CCCCC2Oc1ccc(cc1)C(C)(C)C
Properties
Chemical formula	C19H26O4S
Molar mass	350.47 g·mol−1
Appearance	dark amber viscous liquid
Density	1.10 g/cm3
Solubility in water	0.5 ppm
Solubility	miscible in organic solvents
Hazards
Safety data sheet (SDS)	Cornell University
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Chemical compound

Propargite (IUPAC name 2-(4-tert-butylphenoxy)cyclohexyl prop-2-yne-1-sulfonate, trade names Mitex, Omite and Comite) is a pesticide used to kill mites (an acaricide).^[2] It acts through inhibition of mitochondrial ATP synthase, and is in IRAC group 12C.^[3] Symptoms of excessive exposure are eye and skin irritation, and possibly sensitization. It is highly toxic to amphibians, fish, and zooplankton, as well as having potential carcinogenity.^[4]

References

[edit]

1. ^ Lide, David R. (1998), Handbook of Chemistry and Physics (87 ed.), Boca Raton, Florida: CRC Press, pp. 3–482, ISBN 978-0-8493-0594-8
2. ^ ^{a b} "propargite (Omite, Comite) Chemical Fact Sheet 9/86". Cornell University. 1986-09-30. Retrieved 2009-12-02.
3. ^ Kadir, Habsah A.; Knowles, Charles O. (1 June 1991). "Inhibition of ATP Dephosphorylation by Acaricides with Emphasis on the Anti-ATPase Activity of the Carbodiimide Metabolite of Diafenthiuron". Journal of Economic Entomology. 84 (3): 801–805. doi:10.1093/jee/84.3.801. PMID 1832178.
4. ^ "Integrated Risk Information System". 2013-03-15.{{cite web}}: CS1 maint: deprecated archival service (link)

http://onlinelibrary.wiley.com/doi/10.2903/j.efsa.2011.2087/epdf

External links

[edit]

• Propargite in the Pesticide Properties DataBase (PPDB)

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