PLSCR4

Phospholipid scramblase 4, also known as Ca2+-dependent phospholipid scramblase 4, is a protein that is encoded in humans by the PLSCR4 gene.

Protein-coding gene in the species Homo sapiens

PLSCR4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3Q5U
Identifiers
Aliases	PLSCR4, TRA1, phospholipid scramblase 4
External IDs	OMIM: 607612; MGI: 2143267; HomoloGene: 23217; GeneCards: PLSCR4; OMA:PLSCR4 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q24 Start 146,192,335 bp[1] End 146,251,179 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 E3.3 Start 92,339,426 bp[2] End 92,374,509 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in germinal epithelium parietal pleura Achilles tendon tibial nerve pericardium visceral pleura ascending aorta Descending thoracic aorta synovial joint optic nerve Top expressed in sciatic nerve iris lumbar spinal ganglion carotid body lung right kidney left lung lobe right lung esophagus ciliary body More reference expression data BioGPS n/a
Gene ontology Molecular function SH3 domain binding phospholipid scramblase activity enzyme binding calcium ion binding CD4 receptor binding protein binding Cellular component integral component of membrane plasma membrane membrane Biological process cellular response to lipopolysaccharide plasma membrane phospholipid scrambling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57088 235527 Ensembl ENSG00000114698 ENSMUSG00000032377 UniProt Q9NRQ2 P58196 RefSeq (mRNA) NM_001128304 NM_001128305 NM_001128306 NM_001177304 NM_020353 NM_178711 RefSeq (protein) NP_001121776 NP_001121777 NP_001121778 NP_001170775 NP_065086 NP_848826 Location (UCSC) Chr 3: 146.19 – 146.25 Mb Chr 9: 92.34 – 92.37 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Phospholipid scramblase 4, also known as Ca²⁺-dependent phospholipid scramblase 4, is a protein that is encoded in humans by the PLSCR4 gene.^[5][6]

See also

[edit]

• Scramblase

References

[edit]

1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000114698 – Ensembl, May 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000032377 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ "Entrez Gene: phospholipid scramblase 4".
6. ^ Wiedmer T, Zhou Q, Kwoh DY, Sims PJ (July 2000). "Identification of three new members of the phospholipid scramblase gene family". Biochim. Biophys. Acta. 1467 (1): 244–53. doi:10.1016/S0005-2736(00)00236-4. PMID 10930526.

Further reading

[edit]

• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Rose JE, Behm FM, Drgon T, et al. (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Shibata H, Suzuki H, Kakiuchi T, et al. (2008). "Identification of Alix-type and Non-Alix-type ALG-2-binding sites in human phospholipid scramblase 3: differential binding to an alternatively spliced isoform and amino acid-substituted mutants". J. Biol. Chem. 283 (15): 9623–32. doi:10.1074/jbc.M800717200. PMID 18256029.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Sahu SK, Aradhyam GK, Gummadi SN (2009). "Calcium binding studies of peptides of human phospholipid scramblases 1 to 4 suggest that scramblases are new class of calcium binding proteins in the cell". Biochim. Biophys. Acta. 1790 (10): 1274–81. doi:10.1016/j.bbagen.2009.06.008. PMID 19540310.
• Py B, Basmaciogullari S, Bouchet J, et al. (2009). "The phospholipid scramblases 1 and 4 are cellular receptors for the secretory leukocyte protease inhibitor and interact with CD4 at the plasma membrane". PLOS ONE. 4 (3) e5006. Bibcode:2009PLoSO...4.5006P. doi:10.1371/journal.pone.0005006. PMC 2659420. PMID 19333378.

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