Oxolamine

Oxolamine is a cough suppressant that is available as a generic drug in many jurisdictions. Oxolamine also has anti-inflammatory activity, which causes a reduction in irritation of the nerve receptors of the respiratory tract. It is mainly used for the treatment of pharyngitis, tracheitis, bronchitis, bronchiectasis and pertussis. Oxolamine is not approved in the USA, it may be marketed elsewhere internationally as a cough suppressant. It is listed as a prescription drug in New Zealand legislation. Oxolamine is also approved in Taiwan for the treatment of respiratory tract inflammation.

Cough suppressant

Pharmaceutical compound

Oxolamine

Clinical data
AHFS/Drugs.com	International Drug Names
ATC code	R05DB07 (WHO)
Identifiers
IUPAC name N,N-diethyl-2-(3-phenyl-1,2,4-oxadiazol-5-yl)ethanamine
CAS Number	959-14-8 Y
PubChem CID	13738
DrugBank	DB13216 Y
ChemSpider	13143 Y
UNII	90BEA145GY
KEGG	D07387 Y
ChEMBL	ChEMBL1620875 N
CompTox Dashboard (EPA)	DTXSID5023403
ECHA InfoCard	100.012.267
Chemical and physical data
Formula	C14H19N3O
Molar mass	245.326 g·mol−1
3D model (JSmol)	Interactive image
SMILES n1c(onc1c2ccccc2)CCN(CC)CC
InChI InChI=1S/C14H19N3O/c1-3-17(4-2)11-10-13-15-14(16-18-13)12-8-6-5-7-9-12/h5-9H,3-4,10-11H2,1-2H3 Y Key:IDCHQQSVJAAUQQ-UHFFFAOYSA-N Y
NY (what is this?)  (verify)

Oxolamine is a cough suppressant^[1] that is available as a generic drug in many jurisdictions.^[2]

Oxolamine also has anti-inflammatory activity, which causes a reduction in irritation of the nerve receptors of the respiratory tract.^[3]

It is mainly used for the treatment of pharyngitis, tracheitis, bronchitis, bronchiectasis and pertussis.^[3]

Oxolamine is not approved in the USA, it may be marketed elsewhere internationally as a cough suppressant. It is listed as a prescription drug in New Zealand legislation. Oxolamine is also approved in Taiwan for the treatment of respiratory tract inflammation.^[4]

References

[edit]

1. ^ de Groot AC (2022). "3.357 Oxolamine". Systemic Drugs. Monographs in Contact Allergy. Vol. 4 (First ed.). CRC Press. p. 712. ISBN 978-1-00-054991-1.
2. ^ "Oxolamine". drugs.com. 19 April 2015. Archived from the original on 20 September 2018. Retrieved 23 January 2018.
3. ^ ^{a b} "NCATS Inxight Drugs — OXOLAMINE CITRATE". drugs.ncats.io. Archived from the original on 2022-09-26. Retrieved 2022-09-26.
4. ^ "Oxolamine". go.drugbank.com. Archived from the original on 2022-09-26. Retrieved 2022-09-26.

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