NEURL

Neuralized-like protein 1 is a protein that in humans is encoded by the NEURL gene.

Protein-coding gene in the species Homo sapiens

NEURL1
Identifiers
Aliases	NEURL1, NEUR1, NEURL, RNF67, bA416N2.1, neu, neu-1, neuralized E3 ubiquitin protein ligase 1
External IDs	OMIM: 603804; MGI: 1334263; HomoloGene: 32503; GeneCards: NEURL1; OMA:NEURL1 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q24.33 Start 103,493,705 bp[1] End 103,592,546 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19 C3|19 39.39 cM Start 47,167,259 bp[2] End 47,247,880 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in muscle of thigh right hemisphere of cerebellum gastrocnemius muscle right frontal lobe cingulate gyrus anterior cingulate cortex prefrontal cortex nucleus accumbens Brodmann area 9 amygdala Top expressed in muscle of thigh superior frontal gyrus triceps brachii muscle primary visual cortex temporal muscle dentate gyrus of hippocampal formation granule cell sternocleidomastoid muscle skeletal muscle tissue digastric muscle vastus lateralis muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function translation factor activity, non-nucleic acid binding ubiquitin protein ligase activity metal ion binding ubiquitin-protein transferase activity transferase activity Cellular component cytoplasm perikaryon postsynaptic membrane cell projection membrane postsynaptic density plasma membrane dendritic spine synapse cell junction dendrite perinuclear region of cytoplasm apical dendrite Biological process Notch signaling pathway flagellated sperm motility positive regulation of epidermal growth factor-activated receptor activity positive regulation of dendritic spine development protein monoubiquitination nervous system development sperm axoneme assembly positive regulation of synapse maturation brain development positive regulation of long-term neuronal synaptic plasticity protein ubiquitination positive regulation of apoptotic process cellular response to amino acid stimulus lactation skeletal muscle tissue development positive regulation of filopodium assembly regulation of translation negative regulation of cell population proliferation negative regulation of Notch signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9148 18011 Ensembl ENSG00000107954 ENSMUSG00000006435 UniProt O76050 Q923S6 RefSeq (mRNA) NM_004210 NM_001163480 NM_021360 RefSeq (protein) NP_004201 NP_001156952 NP_067335 Location (UCSC) Chr 10: 103.49 – 103.59 Mb Chr 19: 47.17 – 47.25 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Neuralized-like protein 1 is a protein that in humans is encoded by the NEURL gene.^[5][6]

See also

[edit]

• NEURL2 (gene)

References

[edit]

1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000107954 – Ensembl, May 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000006435 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Nakamura H, Yoshida M, Tsuiki H, Ito K, Ueno M, Nakao M, Oka K, Tada M, Kochi M, Kuratsu J, Ushio Y, Saya H (Apr 1998). "Identification of a human homolog of the Drosophila neuralized gene within the 10q25.1 malignant astrocytoma deletion region". Oncogene. 16 (8): 1009–19. doi:10.1038/sj.onc.1201618. PMID 9519875.
6. ^ "Entrez Gene: NEURL neuralized homolog (Drosophila)".

Further reading

[edit]

• Kile BT, Schulman BA, Alexander WS, et al. (2002). "The SOCS box: a tale of destruction and degradation". Trends Biochem. Sci. 27 (5): 235–41. doi:10.1016/S0968-0004(02)02085-6. PMID 12076535.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Timmusk T, Palm K, Belluardo N, et al. (2002). "Dendritic localization of mammalian neuralized mRNA encoding a protein with transcription repression activities". Mol. Cell. Neurosci. 20 (4): 649–68. doi:10.1006/mcne.2002.1148. PMID 12213446. S2CID 25771738.
• Pavlopoulos E, Kokkinaki M, Koutelou E, et al. (2002). "Cloning, chromosomal organization and expression analysis of Neurl, the mouse homolog of Drosophila melanogaster neuralized gene". Biochim. Biophys. Acta. 1574 (3): 375–82. doi:10.1016/s0167-4781(01)00330-x. PMID 11997106.
• Vollrath B, Pudney J, Asa S, et al. (2001). "Isolation of a Murine Homologue of the Drosophila neuralized Gene, a Gene Required for Axonemal Integrity in Spermatozoa and Terminal Maturation of the Mammary Gland". Mol. Cell. Biol. 21 (21): 7481–94. doi:10.1128/MCB.21.21.7481-7494.2001. PMC 99920. PMID 11585928.

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