Monocyte distribution width

Monocyte distribution width
Monocyte distribution width
Synonyms	MDW
Purpose	measure of the range of variation of monocyte volume

Monocyte distribution width (MDW) is a cytometry-based parameter that measures the range of variation of monocytes. If the parameter is available, it is reported as part of the standard complete blood count (CBC) with differential.^[1]

The parameter was FDA cleared as an early sepsis indicator for ER patients in 2019 for Beckman Coulter.^[2]^[3]

MDW serves as an indicator for early screening of sepsis in conjunction with CRP and PCT and for differentiating false positive blood cultures.^[4]^[5]

References

^ Bentahar, Ahmed (Sep 1, 2022). "What is Monocyte Distribution Width". Beckman Coulter.
^ "Beckman Coulter's Early Sepsis Indicator Receives 510(k) Clearance from the U.S. Food and Drug Administration". www.beckmancoulter.com. April 18, 2019.
^ "FDA Product Classification". FDA.
^ Jo, Sung Jin; Kim, Sei Won; Choi, Jung-Hyun; Choi, Seoung Pill; Lee, Jehoon; Lim, Jihyang (20 December 2022). "Monocyte distribution width (MDW) as a useful indicator for early screening of sepsis and discriminating false positive blood cultures". PLOS ONE. 17 (12) e0279374. Bibcode:2022PLoSO..1779374J. doi:10.1371/journal.pone.0279374. PMC 9767324. PMID 36538555.
^ Paxton, Anne (18 July 2023). "For sepsis Dx, MDW biomarker brought into the mix - CAP TODAY". CAP Today. Retrieved 16 April 2024.

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[bcMDW1-1] Bentahar, Ahmed (Sep 1, 2022). "What is Monocyte Distribution Width". Beckman Coulter.

[2] "Beckman Coulter's Early Sepsis Indicator Receives 510(k) Clearance from the U.S. Food and Drug Administration". www.beckmancoulter.com. April 18, 2019.

[3] "FDA Product Classification". FDA.

[4] Jo, Sung Jin; Kim, Sei Won; Choi, Jung-Hyun; Choi, Seoung Pill; Lee, Jehoon; Lim, Jihyang (20 December 2022). "Monocyte distribution width (MDW) as a useful indicator for early screening of sepsis and discriminating false positive blood cultures". PLOS ONE. 17 (12) e0279374. Bibcode:2022PLoSO..1779374J. doi:10.1371/journal.pone.0279374. PMC 9767324. PMID 36538555.

[5] Paxton, Anne (18 July 2023). "For sepsis Dx, MDW biomarker brought into the mix - CAP TODAY". CAP Today. Retrieved 16 April 2024.

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v t e Hematology blood tests
Complete blood count	Hemoglobin Hematocrit Red blood cell count Red blood cell indices Mean corpuscular hemoglobin Mean corpuscular hemoglobin concentration Mean corpuscular volume Red blood cell distribution width White blood cell count White blood cell differential Absolute neutrophil count Platelet count Mean platelet volume Reticulocyte count Reticulocyte index
Other tests of red blood cells	Blood volume Total blood volume (TBV) Plasma volume (PV) Red cell volume (RCV) Fetal hemoglobin Apt–Downey test Kleihauer–Betke test Hemoglobinopathy testing Hemoglobin electrophoresis Sickle solubility test Mentzer index Erythrocyte sedimentation rate Haptoglobin Monocyte distribution width (MDW) Osmotic fragility
Coagulation	Clotting factors Prothrombin time Partial thromboplastin time Thrombin time Activated clotting time Fibrinogen Bleeding time animal enzyme Reptilase time Ecarin clotting time Dilute Russell's viper venom time Thrombin generation assay Calibrated automated thrombogram ST Genesia-based test Thromboelastography Thrombodynamics test Overall hemostatic potential Coagulation activation markers Prothrombin fragments 1+2 Thrombin–antithrombin complex Fibrinopeptide A Fibrin monomers Activated protein C–protein C inhibitor Fibrinolysis Euglobulin lysis time D-Dimer Plasmin-α₂-antiplasmin complex Von Willebrand factor Ristocetin-induced platelet aggregation Activated protein C resistance test aPTT-based activated protein C resistance test ETP-based activated protein C resistance test
Other	Blood film Blood viscosity Nitro blue tetrazolium chloride test Flow cytometry Immunophenotyping