LSM4

U6 snRNA-associated Sm-like protein LSm4 is a protein that in humans is encoded by the LSM4 gene. Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM]

Protein-coding gene in the species Homo sapiens

LSM4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3JCR
Identifiers
Aliases	LSM4, GRP, YER112W, LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated
External IDs	OMIM: 607284; MGI: 1354692; HomoloGene: 134555; GeneCards: LSM4; OMA:LSM4 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.11 Start 18,306,236 bp[1] End 18,323,112 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 B3.3 Start 71,125,898 bp[2] End 71,131,402 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon right testis left testis ventricular zone right adrenal gland right adrenal cortex left adrenal cortex embryo ganglionic eminence apex of heart Top expressed in yolk sac thymus bone marrow lens epiblast ventricular zone proximal tubule embryo ileum ganglionic eminence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding U6 snRNA binding RNA binding PH domain binding Cellular component spliceosomal tri-snRNP complex U6 snRNP P-body nucleoplasm neuron projection spliceosomal complex nucleus cytosol membrane protein-containing complex U4/U6 x U5 tri-snRNP complex U2-type precatalytic spliceosome Lsm2-8 complex Biological process RNA processing mRNA processing spliceosomal snRNP assembly spliceosomal complex assembly P-body assembly exonucleolytic catabolism of deadenylated mRNA RNA splicing mRNA splicing, via spliceosome nuclear-transcribed mRNA catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 25804 50783 Ensembl ENSG00000130520 ENSMUSG00000031848 UniProt Q9Y4Z0 Q9QXA5 RefSeq (mRNA) NM_012321 NM_001252129 NM_015816 NM_001359042 RefSeq (protein) NP_001239058 NP_036453 NP_056631 NP_001345971 Location (UCSC) Chr 19: 18.31 – 18.32 Mb Chr 8: 71.13 – 71.13 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

U6 snRNA-associated Sm-like protein LSm4 is a protein that in humans is encoded by the LSM4 gene.^[5][6][7]

Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM]^[7]

References

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1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000130520 – Ensembl, May 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000031848 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Salgado-Garrido J, Bragado-Nilsson E, Kandels-Lewis S, Seraphin B (Aug 1999). "Sm and Sm-like proteins assemble in two related complexes of deep evolutionary origin". EMBO J. 18 (12): 3451–62. doi:10.1093/emboj/18.12.3451. PMC 1171424. PMID 10369684.
6. ^ Achsel T, Brahms H, Kastner B, Bachi A, Wilm M, Luhrmann R (Dec 1999). "A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro". EMBO J. 18 (20): 5789–802. doi:10.1093/emboj/18.20.5789. PMC 1171645. PMID 10523320.
7. ^ ^{a b} "Entrez Gene: LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)".

Further reading

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• Singer J, Roberts-Ems J, Luthardt FW, Riggs AD (1980). "Methylation of DNA in mouse early embryos, teratocarcinoma cells and adult tissues of mouse and rabbit". Nucleic Acids Res. 7 (8): 2369–85. doi:10.1093/nar/7.8.2369. PMC 342390. PMID 523320.
• Friesen WJ, Dreyfuss G (2000). "Specific sequences of the Sm and Sm-like (Lsm) proteins mediate their interaction with the spinal muscular atrophy disease gene product (SMN)". J. Biol. Chem. 275 (34): 26370–5. doi:10.1074/jbc.M003299200. PMID 10851237.
• Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. Bibcode:2000PNAS...97.9543H. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946.
• Eystathioy T, Peebles CL, Hamel JC, et al. (2002). "Autoantibody to hLSm4 and the heptameric LSm complex in anti-Sm sera". Arthritis Rheum. 46 (3): 726–34. doi:10.1002/art.10220. PMID 11920408.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ingelfinger D, Arndt-Jovin DJ, Lührmann R, Achsel T (2003). "The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci". RNA. 8 (12): 1489–501. doi:10.1017/S1355838202021726. PMC 1370355. PMID 12515382.
• Lehner B, Sanderson CM (2004). "A Protein Interaction Framework for Human mRNA Degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Fürst J, Schedlbauer A, Gandini R, et al. (2005). "ICln159 folds into a pleckstrin homology domain-like structure. Interaction with kinases and the splicing factor LSm4". J. Biol. Chem. 280 (35): 31276–82. doi:10.1074/jbc.M500541200. PMID 15905169.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Yang ZQ, Streicher KL, Ray ME, et al. (2007). "Multiple interacting oncogenes on the 8p11-p12 amplicon in human breast cancer". Cancer Res. 66 (24): 11632–43. doi:10.1158/0008-5472.CAN-06-2946. PMID 17178857.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1) 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

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