HAS3

Hyaluronan synthase 3 is an enzyme that in humans is encoded by the HAS3 gene. The protein encoded by this gene is involved in the synthesis of the unbranched glycosaminoglycan hyaluronan, or hyaluronic acid, which is a major constituent of the extracellular matrix. This gene is a member of the NODC/HAS gene family. Compared to the proteins encoded by other members of this gene family, this protein appears to be more of a regulator of hyaluronan synthesis. Two transcript variants encoding different isoforms have been found for this gene.

Protein-coding gene in the species Homo sapiens

HAS3
Identifiers
Aliases	HAS3, hyaluronan synthase 3
External IDs	OMIM: 602428; MGI: 109599; HomoloGene: 68461; GeneCards: HAS3; OMA:HAS3 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q22.1 Start 69,105,653 bp[1] End 69,118,719 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 D3|8 53.28 cM Start 107,596,874 bp[2] End 107,611,198 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte cartilage tissue mucosa of esophagus urinary bladder tendon of biceps brachii mucosa of transverse colon vagina testicle olfactory zone of nasal mucosa skin of abdomen Top expressed in inner enamel epithelium stratum intermedium hair follicle secondary oocyte hair primary oocyte mandibular molars zygote tail of embryo lip More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity glycosyltransferase activity hyaluronan synthase activity protein binding identical protein binding Cellular component cytoplasm integral component of membrane plasma membrane hyaluranon cable integral component of plasma membrane membrane Biological process positive regulation of transcription, DNA-templated cell adhesion hyaluronan biosynthetic process extracellular matrix assembly positive regulation of hyaluranon cable assembly extracellular polysaccharide biosynthetic process carbohydrate metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3038 15118 Ensembl ENSG00000103044 ENSMUSG00000031910 UniProt O00219 O08650 RefSeq (mRNA) NM_001199280 NM_005329 NM_138612 NM_008217 NM_001331048 RefSeq (protein) NP_001186209 NP_005320 NP_619515 NP_001317977 NP_032243 Location (UCSC) Chr 16: 69.11 – 69.12 Mb Chr 8: 107.6 – 107.61 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Hyaluronan synthase 3 is an enzyme that in humans is encoded by the HAS3 gene.^[5][6][7]

The protein encoded by this gene is involved in the synthesis of the unbranched glycosaminoglycan hyaluronan, or hyaluronic acid, which is a major constituent of the extracellular matrix. This gene is a member of the NODC/HAS gene family. Compared to the proteins encoded by other members of this gene family, this protein appears to be more of a regulator of hyaluronan synthesis. Two transcript variants encoding different isoforms have been found for this gene.^[7]

References

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1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000103044 – Ensembl, May 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000031910 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Spicer AP, Seldin MF, Olsen AS, Brown N, Wells DE, Doggett NA, Itano N, Kimata K, Inazawa J, McDonald JA (Jul 1997). "Chromosomal localization of the human and mouse hyaluronan synthase genes". Genomics. 41 (3): 493–7. doi:10.1006/geno.1997.4696. PMID 9169154.
6. ^ Spicer AP, Olson JS, McDonald JA (May 1997). "Molecular cloning and characterization of a cDNA encoding the third putative mammalian hyaluronan synthase". J Biol Chem. 272 (14): 8957–61. doi:10.1074/jbc.272.14.8957. PMID 9083017.
7. ^ ^{a b} "Entrez Gene: HAS3 hyaluronan synthase 3".

Further reading

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• Jacobson A, Brinck J, Briskin MJ, et al. (2000). "Expression of human hyaluronan synthases in response to external stimuli". Biochem. J. 348. Pt 1 (1): 29–35. doi:10.1042/0264-6021:3480029. PMC 1221032. PMID 10794710.
• Simpson MA, Reiland J, Burger SR, et al. (2001). "Hyaluronan synthase elevation in metastatic prostate carcinoma cells correlates with hyaluronan surface retention, a prerequisite for rapid adhesion to bone marrow endothelial cells". J. Biol. Chem. 276 (21): 17949–57. doi:10.1074/jbc.M010064200. PMID 11278609.
• Kuroda K, Utani A, Hamasaki Y, Shinkai H (2001). "Up-regulation of putative hyaluronan synthase mRNA by basic fibroblast growth factor and insulin-like growth factor-1 in human skin fibroblasts". J. Dermatol. Sci. 26 (2): 156–60. doi:10.1016/S0923-1811(00)00155-9. PMID 11378333.
• Liu N, Gao F, Han Z, et al. (2001). "Hyaluronan synthase 3 overexpression promotes the growth of TSU prostate cancer cells". Cancer Res. 61 (13): 5207–14. PMID 11431361.
• Simpson MA, Wilson CM, Furcht LT, et al. (2002). "Manipulation of hyaluronan synthase expression in prostate adenocarcinoma cells alters pericellular matrix retention and adhesion to bone marrow endothelial cells". J. Biol. Chem. 277 (12): 10050–7. doi:10.1074/jbc.M110069200. PMID 11790779.
• Sayo T, Sugiyama Y, Takahashi Y, et al. (2002). "Hyaluronan synthase 3 regulates hyaluronan synthesis in cultured human keratinocytes". J. Invest. Dermatol. 118 (1): 43–8. doi:10.1046/j.0022-202x.2001.01613.x. PMID 11851874.
• Chagnon P, Michaud J, Mitchell G, et al. (2003). "A missense mutation (R565W) in cirhin (FLJ14728) in North American Indian childhood cirrhosis". Am. J. Hum. Genet. 71 (6): 1443–9. doi:10.1086/344580. PMC 378590. PMID 12417987.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Bullard KM, Kim HR, Wheeler MA, et al. (2004). "Hyaluronan synthase-3 is upregulated in metastatic colon carcinoma cells and manipulation of expression alters matrix retention and cellular growth". Int. J. Cancer. 107 (5): 739–46. doi:10.1002/ijc.11475. PMID 14566823. S2CID 24405794.
• Suzuki K, Yamamoto T, Usui T, et al. (2004). "Expression of hyaluronan synthase in intraocular proliferative diseases: regulation of expression in human vascular endothelial cells by transforming growth factor-beta". Jpn. J. Ophthalmol. 47 (6): 557–64. doi:10.1016/j.jjo.2003.09.001. PMID 14636845.
• Grskovic B, Pollaschek C, Mueller MM, Stuhlmeier KM (2006). "Expression of hyaluronan synthase genes in umbilical cord blood stem/progenitor cells". Biochim. Biophys. Acta. 1760 (6): 890–5. doi:10.1016/j.bbagen.2006.02.002. PMID 16564133.
• Campo GM, Avenoso A, Campo S, et al. (2007). "TNF-alpha, IFN-gamma, and IL-1beta modulate hyaluronan synthase expression in human skin fibroblasts: synergistic effect by concomital treatment with FeSO4 plus ascorbate". Mol. Cell. Biochem. 292 (1–2): 169–78. doi:10.1007/s11010-006-9230-7. PMID 16786194. S2CID 37598580.

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