GFM2

Ribosome-releasing factor 2, mitochondrial is a protein that in humans is encoded by the GFM2 gene. Unlike the other EF-G homolog GFM1, GFM2 functions as a Ribosome Recycling Factor in termination.

Protein-coding gene in the species Homo sapiens

GFM2
Identifiers
Aliases	GFM2, EF-G2mt, EFG2, MRRF2, MST027, RRF2, RRF2mt, hEFG2, mEF-G 2, MSTP027, G elongation factor, mitochondrial 2, G elongation factor mitochondrial 2, RRF, GTP dependent ribosome recycling factor mitochondrial 2
External IDs	OMIM: 606544; MGI: 2444783; HomoloGene: 6238; GeneCards: GFM2; OMA:GFM2 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q13.3 Start 74,721,206 bp[1] End 74,767,147 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 D1 Start 97,274,445 bp[2] End 97,317,703 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in myocardium of left ventricle tibialis anterior muscle bronchial epithelial cell deltoid muscle epithelium of nasopharynx secondary oocyte mucosa of ileum cardiac muscle tissue of right atrium right uterine tube nasal epithelium Top expressed in muscle of thigh otic vesicle sternocleidomastoid muscle otic placode temporal muscle right kidney saccule triceps brachii muscle digastric muscle skeletal muscle tissue More reference expression data BioGPS n/a
Gene ontology Molecular function translation elongation factor activity nucleotide binding GTP binding protein binding GTPase activity Cellular component mitochondrial matrix mitochondrion Biological process mitochondrial translational termination mitochondrial translational elongation ribosome disassembly protein biosynthesis mitochondrial translation translational elongation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84340 320806 Ensembl ENSG00000164347 ENSMUSG00000021666 UniProt Q969S9 Q8R2Q4 RefSeq (mRNA) NM_001281302 NM_032380 NM_170681 NM_170691 NM_001146043 NM_001271463 NM_001271464 NM_001271465 NM_177266 RefSeq (protein) NP_001268231 NP_115756 NP_733781 NP_733792 NP_733792.1 NP_001139515 NP_001258392 NP_001258393 NP_001258394 NP_796240 Location (UCSC) Chr 5: 74.72 – 74.77 Mb Chr 13: 97.27 – 97.32 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Ribosome-releasing factor 2, mitochondrial is a protein that in humans is encoded by the GFM2 gene.^[5][6] Unlike the other EF-G homolog GFM1, GFM2 functions as a Ribosome Recycling Factor in termination.^[7]

References

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1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000164347 – Ensembl, May 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000021666 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Hammarsund M, Wilson W, Corcoran M, Merup M, Einhorn S, Grandér D, Sangfelt O (November 2001). "Identification and characterization of two novel human mitochondrial elongation factor genes, hEFG2 and hEFG1, phylogenetically conserved through evolution". Human Genetics. 109 (5): 542–50. doi:10.1007/s00439-001-0610-5. PMID 11735030. S2CID 24508386.
6. ^ "Entrez Gene: GFM2 G elongation factor, mitochondrial 2".
7. ^ Tsuboi M, Morita H, Nozaki Y, Akama K, Ueda T, Ito K, Nierhaus KH, Takeuchi N (August 2009). "EF-G2mt is an exclusive recycling factor in mammalian mitochondrial protein synthesis". Molecular Cell. 35 (4): 502–10. doi:10.1016/j.molcel.2009.06.028. PMID 19716793.

External links

[edit]

• InterPro: IPR030851

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