Fluopyram

Fluopyram
Names
	Preferred IUPAC name N-{2-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]ethyl}-2-(trifluoromethyl)benzamide
Identifiers
CAS Number	658066-35-4 ;
3D model (JSmol)	Interactive image;
ChemSpider	9333461;
ECHA InfoCard	100.127.749
PubChem CID	11158353;
UNII	F0VT7K5302 ;
CompTox Dashboard (EPA)	DTXSID9058151 ;
	InChI InChI=1S/C16H11ClF6N2O/c17-12-7-9(15(18,19)20)8-25-13(12)5-6-24-14(26)10-3-1-2-4-11(10)16(21,22)23/h1-4,7-8H,5-6H2,(H,24,26) Key: KVDJTXBXMWJJEF-UHFFFAOYSA-N;
	SMILES FC(F)(F)c1ccccc1C(=O)NCCc2ncc(cc2Cl)C(F)(F)F;
Properties
Chemical formula	C16H11ClF6N2O
Molar mass	396.72 g·mol−1
Melting point	117.5 °C (243.5 °F; 390.6 K)
Boiling point	318–321 °C (604–610 °F; 591–594 K)
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Fluopyram is a synthetic fungicide and nematicide used in agriculture.^[2]^[3] It is used to control fungal diseases such as gray mold (Botrytis cinerea), powdery mildew, apple scab, Alternaria, Sclerotinia, and Monilinia. It is an inhibitor of succinate dehydrogenase (SDHI fungicide).^[4]

Regulation

Developed and produced by Bayer, it was approved in 2012 by the U.S. Environmental Protection Agency^[4] and in 2013 it was approved in the EU for use as an active ingredient in pesticides.^[5]

Pesticide products containing fluopyram have been banned in Denmark because the chemical can degrade into trifluoroacetic acid, which can then contaminate groundwater and not decompose.^[6]

References

^ ^a ^b "Fluopyram" (PDF). Food and Agriculture Organization of the United Nations.
^ Grabau, Zane J.; Liu, Chang; Schumacher, Lesley A.; Small, Ian M.; Wright, David L. (February 2021). "In-furrow fluopyram nematicide efficacy for Rotylenchulus reniformis management in cotton production". Crop Protection. 140 105423. Bibcode:2021CrPro.14005423G. doi:10.1016/j.cropro.2020.105423. S2CID 226354918.
^ Faske, TR; Hurd, K (December 2015). "Sensitivity of Meloidogyne incognita and Rotylenchulus reniformis to Fluopyram". Journal of Nematology. 47 (4): 316–21. PMC 4755706. PMID 26941460.
^ ^a ^b "Fluopyram". New Active Ingredient Review. Minnesota Department of Agriculture. April 2012. Archived from the original on 2017-04-26. Retrieved 2015-09-16.
^ "Durchführungsverordnung (EU) Nr. 802/2013 Der Kommission" (in German). August 2013.
^ "Denmark bans more PFAS pesticides to protect groundwater". Pesticide Action Network Europe. October 6, 2025. Retrieved 6 November 2025.

[fao-1] "Fluopyram" (PDF). Food and Agriculture Organization of the United Nations.

[2] Grabau, Zane J.; Liu, Chang; Schumacher, Lesley A.; Small, Ian M.; Wright, David L. (February 2021). "In-furrow fluopyram nematicide efficacy for Rotylenchulus reniformis management in cotton production". Crop Protection. 140 105423. Bibcode:2021CrPro.14005423G. doi:10.1016/j.cropro.2020.105423. S2CID 226354918.

[3] Faske, TR; Hurd, K (December 2015). "Sensitivity of Meloidogyne incognita and Rotylenchulus reniformis to Fluopyram". Journal of Nematology. 47 (4): 316–21. PMC 4755706. PMID 26941460.

[mda-4] "Fluopyram". New Active Ingredient Review. Minnesota Department of Agriculture. April 2012. Archived from the original on 2017-04-26. Retrieved 2015-09-16.

[5] "Durchführungsverordnung (EU) Nr. 802/2013 Der Kommission" (in German). August 2013.

[6] "Denmark bans more PFAS pesticides to protect groundwater". Pesticide Action Network Europe. October 6, 2025. Retrieved 6 November 2025.

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