Core binding factor

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The core binding factor (CBF) is a group of heterodimeric transcription factors.

Core binding factors are composed of:

• a non-DNA-binding CBFβ chain (InterPro: IPR003417)
  • Human: CBFB
• a DNA-binding CBFα chain (InterPro: IPR016554)
  • Human: RUNX1, RUNX2, RUNX3

• de Bruijn M, Speck N (2004). "Core-binding factors in hematopoiesis and immune function". Oncogene. 23 (24): 4238–48. doi:10.1038/sj.onc.1207763. PMID 15156179.

• AI-10-49, an anti-leukemic drug under development.

• Core+Binding+Factors at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

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