Amidephrine

Amidephrine (BANTooltip British Approved Name), or amidefrine, sold under the brand name Fentrinol among others, is a selective α1-adrenergic receptor agonist which is described as an adrenergic or sympathomimetic, vasoconstrictor, and topical nasal decongestant used to treat allergic rhinitis. It is used as the mesylate salt, which has the generic names amidefrine mesilate (INNTooltip International Nonproprietary Name) and amidephrine mesylate (USANTooltip United States Adopted Name). The drug is a substituted phenethylamine derivative and is also known as 3-methylsulfonamidyl-β-hydroxy-N-methylphenethylamine. As of 2000, it remained marketed only in Austria.

Chemical compound

Pharmaceutical compound

Amidephrine

Clinical data
Trade names	Dricol, Fentrinol, Nalde
Other names	Amidefrine; MJ-1996; MJ-5190; 3-Methylsulfonamidyl-β-hydroxy-N-methylphenethylamine; 3-Methylsulfonamidyl-β-hydroxy-N-methyl-β-phenylethylamine
ATC code	None
Identifiers
IUPAC name (RS)-N-{3-[1-hydroxy-2-(methylamino)ethyl]phenyl}methanesulfonamide
CAS Number	37571-84-9 Y 1421-68-7 (mesylate)
PubChem CID	15010
IUPHAR/BPS	514
DrugBank	DB16623
ChemSpider	14288 Y
UNII	7E2P22546V
ChEMBL	ChEMBL146408 Y
CompTox Dashboard (EPA)	DTXSID40862664
Chemical and physical data
Formula	C10H16N2O3S
Molar mass	244.31 g·mol−1
3D model (JSmol)	Interactive image
SMILES O=S(=O)(Nc1cc(ccc1)C(O)CNC)C
InChI InChI=1S/C10H16N2O3S/c1-11-7-10(13)8-4-3-5-9(6-8)12-16(2,14)15/h3-6,10-13H,7H2,1-2H3 Y Key:ZHOWHMXTJFZXRB-UHFFFAOYSA-N Y
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Amidephrine (BANTooltip British Approved Name), or amidefrine, sold under the brand name Fentrinol among others, is a selective α₁-adrenergic receptor agonist which is described as an adrenergic or sympathomimetic, vasoconstrictor, and topical nasal decongestant used to treat allergic rhinitis.^{[1][2][3][4][5]} It is used as the mesylate salt, which has the generic names amidefrine mesilate (INNTooltip International Nonproprietary Name) and amidephrine mesylate (USANTooltip United States Adopted Name).^[2] The drug is a substituted phenethylamine derivative and is also known as 3-methylsulfonamidyl-β-hydroxy-N-methylphenethylamine.^[2][1][6] As of 2000, it remained marketed only in Austria.^[3]

References

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1. ^ ^{a b} Elks J (2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer US. p. 40. ISBN 978-1-4757-2085-3. Retrieved 2024-08-31.
2. ^ ^{a b c} Morton IK, Hall JM (2012). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Netherlands. p. 13. ISBN 978-94-011-4439-1. Retrieved 2024-08-31.
3. ^ ^{a b} Schweizerischer Apotheker-Verein (2000). Index Nominum 2000: International Drug Directory. Medpharm Scientific Publishers. p. 39. ISBN 978-3-88763-075-1. Retrieved 2024-08-31.
4. ^ "Amidephrine: Uses, Interactions, Mechanism of Action". DrugBank Online. 24 February 2021. Retrieved 31 August 2024.
5. ^ MacLean MR, Thomson M, Hiley CR (June 1989). "Pressor effects of the alpha 2-adrenoceptor agonist B-HT 933 in anaesthetized and haemorrhagic rats: comparison with the haemodynamic effects of amidephrine". British Journal of Pharmacology. 97 (2): 419–432. doi:10.1111/j.1476-5381.1989.tb11969.x. PMC 1854522. PMID 2569342.
6. ^ "Amidephrine". PubChem. U.S. National Library of Medicine. Retrieved 31 August 2024.

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