APOF

Apolipoprotein F is a protein that in humans is encoded for by the APOF gene. The product of this gene is one of the minor apolipoproteins found in plasma. This protein forms complexes with lipoproteins and may be involved in transport and/or esterification of cholesterol.

Protein-coding gene in the species Homo sapiens

APOF
Identifiers
Aliases	APOF, Apo-F, LTIP, apolipoprotein F
External IDs	OMIM: 107760; MGI: 104539; HomoloGene: 48030; GeneCards: APOF; OMA:APOF - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.3 Start 56,360,568 bp[1] End 56,362,857 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 D3|10 76.5 cM Start 128,103,866 bp[2] End 128,106,022 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver granulocyte islet of Langerhans prostate kidney blood head human musculoskeletal system muscular system muscle Top expressed in left lobe of liver submandibular gland gallbladder seminal vesicula sexually immature organism fetal liver hematopoietic progenitor cell human fetus abdominal wall stomach ureter More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cholesterol binding signaling receptor binding lipid transporter activity Cellular component low-density lipoprotein particle high-density lipoprotein particle extracellular region extracellular space Biological process steroid metabolic process lipid transport cholesterol metabolic process lipid metabolism Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 319 103161 Ensembl ENSG00000175336 ENSMUSG00000047631 UniProt Q13790 Q91V80 RefSeq (mRNA) NM_001638 NM_133997 RefSeq (protein) NP_001629 NP_598758 Location (UCSC) Chr 12: 56.36 – 56.36 Mb Chr 10: 128.1 – 128.11 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Protein family

Apolipoprotein F
Identifiers
Symbol	APOF
Pfam	PF15148
InterPro	IPR026114
Available protein structures: PDB   IPR026114 PF15148 (ECOD; PDBsum)   AlphaFold IPR026114 PF15148

Apolipoprotein F is a protein that in humans is encoded for by the APOF gene.^[5][6] The product of this gene is one of the minor apolipoproteins found in plasma. This protein forms complexes with lipoproteins and may be involved in transport and/or esterification of cholesterol.^[6]

References

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1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000175336 – Ensembl, May 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000047631 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Day JR, Albers JJ, Gilbert TL, Whitmore TE, McConathy WJ, Wolfbauer G (Oct 1994). "Purification and molecular cloning of human apolipoprotein F". Biochem Biophys Res Commun. 203 (2): 1146–51. doi:10.1006/bbrc.1994.2302. PMID 8093033.
6. ^ ^{a b} "Entrez Gene: APOF apolipoprotein F".

External links

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• Human APOF genome location and APOF gene details page in the UCSC Genome Browser.

Further reading

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• Morton RE, Gnizak HM, Greene DJ, et al. (2008). "Lipid transfer inhibitor protein (apolipoprotein F) concentration in normolipidemic and hyperlipidemic subjects". J. Lipid Res. 49 (1): 127–35. doi:10.1194/jlr.M700258-JLR200. PMID 17901467.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kabbara A, Payet N, Cottel D, et al. (2004). "Exclusion of CYP46 and APOM as candidate genes for Alzheimer's disease in a French population". Neurosci. Lett. 363 (2): 139–43. doi:10.1016/j.neulet.2004.03.066. PMID 15172102. S2CID 27752858.
• Anderson NL, Polanski M, Pieper R, et al. (2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources". Mol. Cell. Proteomics. 3 (4): 311–26. doi:10.1074/mcp.M300127-MCP200. PMID 14718574.
• Paromov VM, Morton RE (2003). "Lipid transfer inhibitor protein defines the participation of high density lipoprotein subfractions in lipid transfer reactions mediated by cholesterol ester transfer protein (CETP)". J. Biol. Chem. 278 (42): 40859–66. doi:10.1074/jbc.M306580200. PMID 12907677.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Wang X, Driscoll DM, Morton RE (1999). "Molecular cloning and expression of lipid transfer inhibitor protein reveals its identity with apolipoprotein F". J. Biol. Chem. 274 (3): 1814–20. doi:10.1074/jbc.274.3.1814. PMID 9880564.
• Koren E, McConathy WJ, Alaupovic P (1983). "Isolation and characterization of simple and complex lipoproteins containing apolipoprotein F from human plasma". Biochemistry. 21 (21): 5347–51. doi:10.1021/bi00264a035. PMID 6816269.
• Olofsson SO, McConathy WJ, Alaupovic P (1978). "Isolation and partial characterization of a new acidic apolipoprotein (apolipoprotein F) from high density lipoproteins of human plasma". Biochemistry. 17 (6): 1032–6. doi:10.1021/bi00599a014. PMID 204339.

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